Cdc7 kinase complex: A key regulator in the initiation of DNA replication
Article first published online: 11 JAN 2002
Copyright © 2002 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 190, Issue 3, pages 287–296, March 2002
How to Cite
Masai, H. and Arai, K.-I. (2002), Cdc7 kinase complex: A key regulator in the initiation of DNA replication. J. Cell. Physiol., 190: 287–296. doi: 10.1002/jcp.10070
- Issue published online: 24 JAN 2002
- Article first published online: 11 JAN 2002
- Manuscript Accepted: 24 OCT 2001
- Manuscript Received: 22 OCT 2001
DNA replication results from the action of a staged set of highly regulated processes. Among the stages of DNA replication, initiation is the key point at which all the G1 regulatory signals culminate. Cdc7 kinase is the critical regulator for the ultimate firing of the origins of initiation. Cdc7, originally identified in budding yeast and later in higher eukaryotes, forms a complex with a Dbf4-related regulatory subunit to generate an active kinase. Genetic evidence in mammals demonstrates essential roles for Cdc7 in mammalian DNA replication. Mini-chromosome maintenance protein (MCM) is the major physiological target of Cdc7. Genetic studies in yeasts indicate additional roles of Cdc7 in meiosis, checkpoint responses, maintenance of chromosome structures, and repair. The interplay between Cdc7 and Cdk, another kinase essential for the S phase, is also discussed. J. Cell. Physiol. 190: 287–296, 2002. © 2002 Wiley-Liss, Inc.