Role of N-cadherin in bone formation
Article first published online: 11 JAN 2002
Copyright © 2002 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 190, Issue 3, pages 297–305, March 2002
How to Cite
Marie, P. J. (2002), Role of N-cadherin in bone formation. J. Cell. Physiol., 190: 297–305. doi: 10.1002/jcp.10073
- Issue published online: 24 JAN 2002
- Article first published online: 11 JAN 2002
- Manuscript Accepted: 9 NOV 2001
- Manuscript Received: 12 SEP 2001
Cell–cell adhesion mediated by cadherins is essential for the function of bone forming cells during osteogenesis. Here, the evidence that N-cadherin is an important regulator of osteoblast differentiation and osteogenesis is reviewed. Osteoblasts express a limited number of cadherins, including the classic N-cadherin. The expression profile of N-cadherin in osteoblasts during bone formation in vivo and in vitro suggests a role of this molecule in osteogenesis. Functional studies using neutralizing antibodies or antisense oligonucleotides indicate that N-cadherin is involved in the control the expression of osteoblast marker gene expression and differentiation. Cleavage of N-cadherin during osteoblast apoptosis also suggests a role of N-cadherin-mediated-cell–cell adhesion in osteoblast survival. Hormonal and local factors that regulate osteoblast function also regulate N-cadherin expression and subsequent cell–cell adhesion associated with osteoblast differentiation or survival. Signaling mechanisms involved in N-cadherin-mediated cell–cell adhesion and osteoblast gene expression have also been identified. Alterations of N-cadherin expression are associated with abnormal osteoblast differentiation and osteogenesis in pathological conditions. These findings indicate that N-cadherin plays a role in normal and pathological bone formation and provide some insight into the process involved in N-cadherin-mediated cell–cell adhesion and differentiation in osteoblasts. J. Cell. Physiol. 190: 297–305, 2002. © 2002 Wiley-Liss, Inc.