Interview with the retinoblastoma family members: Do they help each other?
Article first published online: 28 MAY 2002
Copyright © 2002 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 192, Issue 2, pages 138–150, August 2002
How to Cite
Tonini, T., Hillson, C. and Claudio, P. P. (2002), Interview with the retinoblastoma family members: Do they help each other?. J. Cell. Physiol., 192: 138–150. doi: 10.1002/jcp.10117
- Issue published online: 21 JUN 2002
- Article first published online: 28 MAY 2002
- Manuscript Accepted: 1 MAR 2002
- Manuscript Received: 26 FEB 2002
The ultimate destiny of a cell to undergo division, differentiation, survival, and death results from an intricate balance between multiple regulators including oncogenes, tumor suppressor genes, and cell cycle associated proteins. Deregulation of the cell cycle machinery switches the phenotype from a normal cell to a cancerous cell. Fundamental alterations of tumor suppressor genes may result in an unregulated cell cycle with the accumulation of mutations and eventual neoplastic transformation. As such, one may define cancer as a genetic disease of the cell cycle. In this review, we will emphasize our current understanding of how the cell cycle machinery maintains cellular homeostasis by studying the consequences of its deregulation. © 2002 Wiley-Liss, Inc.