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  • Adler V, Yin Z, Tew KD, Ronai Z. 1999a. Role of redox potential and reactive oxygen species in stress signaling. Oncogene 18: 61046111.
  • Adler V, Yin Z, Fuchs SY, Benezra M, Rosario L, Tew KD, Pincus MR, Sardana M, Henderson CJ, Wolf CR, Davis RJ, Ronai Z. 1999b. Regulation of JNK signaling by GSTp. EMBO J 18: 13211334.
  • Aikawa R, Komuro I, Yamazaki T, Zou Y, Kudoh S, Tanaka M, Shiojima I, Hiroi Y, Yazaki Y. 1997. Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats. J Clin Invest 100: 18131821.
  • Alvarez-Tejado M, Naranjo-Suarez S, Jimenez C, Carrera AC, Landazuri MO, del Peso L. 2001. Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. J Biol Chem 276: 2236822374.
  • Andoh T, Lee SY, Chiueh CC. 2000. Preconditioning regulation of bcl-2 and p66shc by human NOS1 enhances tolerance to oxidative stress. FASEB J 14: 21442146.
  • Aoki M, Nata T, Morishita R, Matsushita H, Nakagami H, Yamamoto K, Yamazaki K, Nakabayashi M, Ogihara T, Kaneda Y. 2001. Endothelial apoptosis induced by oxidative stress through activation of nf-kappab: antiapoptotic effect of antioxidant agents on endothelial cells. Hypertension 38: 4855.
  • Arrigo AP. 1998. Small stress proteins: chaperones that act as regulators of intracellular redox state and programmed cell death. J Biol Chem 379: 1926.
  • Asher G, Lotem J, Cohen B, Sachs L, Shaul Y. 2001. Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1. Proc Natl Acad Sci USA 98: 11881193.
  • Baek SH, Min JN, Park EM, Han MY, Lee YS, Lee YJ, Park YM. 2000. Role of small heat shock protein HSP25 in radioresistance and glutathione-redox cycle. J Cell Physiol 183: 100107.
  • Banan A, Fields JZ, Zhang Y, Keshavarzian A. 2001a. Phospholipase C-γ inhibition prevents EGF protection of intestinal cytoskeleton and barrier against oxidants. Am J Physiol Gastrointest Liver Physiol 281: G412G423.
  • Banan A, Fields JZ, Zhang Y, Keshavarian A. 2001b. Key role of PKC and CA2+ in EGF protection of microtubules and intestinal barrier against oxidants. Am J Physiol Gastrointest Liver Physiol 380: G528G543.
  • Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, Chessa L, Smorodinsky NI, Prives C, Reiss Y, Shiloh Y, Ziv Y. 1998. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281: 16741677.
  • Barlow C, Dennery PA, Shigenaga MK, Smith MA, Morrow JD, Robert LJ II, Wynshaw-Boris A, Levine RL. 1991. Loss of ataxia-telangiectasia gene product causes oxidative damage in target organs. Proc Natl Acad Sci USA 96: 99159919.
  • Beraud C, Henzel WJ, Baeuerle PA. 1999. Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation. Proc Natl Acad Sci USA 96: 429434.
  • Bhat NR, Zhang P. 1999. Hydrogen peroxide activation of multiple mitogen-activated protein kinases in an oligodendrocyte cell line: role of extracellular signal-regulated kinase in hydrogen peroxide-induced cell death. J Neurochem 72: 112119.
  • Blake RA, Walker TR, Watson SP. 1993. Activation of human platelets by peroxovanadate is associated with tyrosine phosphorylation of phospholipase C gamma and formation of inositol phosphates. Biochem J 290 (Pt 2): 471475.
  • Bossy-Wetzel E, Bakiri L, Yaniv M. 1997. Induction of apoptosis by the transcription factor c-Jun. EMBO J 16: 16951709.
  • Bours V, Bonizzi G, Bentires-Alj M, Bureau F, Piette J, Lekeux P, Merville M. 2000. NF-kappaB activation in response to toxical and therapeutical agents: role in inflammation and cancer treatment. Toxicology 153: 2738.
  • Bowie A, O'Neill LA. 2000. Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries. Biochem Pharmacol 59: 1323.
  • Brand A, Gil S, Seger R, Yavin E. 2001. Lipid constituents in oligodendroglial cells alter susceptibility to H2O2-induced apoptotic cell death via ERK activation. J Neurochem 76: 910918.
  • Bulavin DV, Saito S, Hollander MC, Sakaguchi K, Anderson CW, Appella E, Fornace AJ, Jr. 1999. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J 18: 68456854.
  • Burdon RH. 1995. Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Radic Biol Med 18: 775794.
  • Burns TF, El Deiry WS. 1999. The p53 pathway and apoptosis. J Cell Physiol 181: 231239.
  • Buschmann T, Yin Z, Bhoumik A, Ronai Z. 2000. Amino-terminal-derived JNK fragment alters expression and activity of c-Jun, ATF2, and p53 and increases H2O2-induced cell death. J Biol Chem 275: 1659016596.
  • Buschmann T, Potapova O, Bar-Shira A, Ivanov VN, Fuchs SY, Henderson S, Fried VA, Minamoto T, Alarcon-Vargas D, Pincus MR, Gaarde WA, Holbrook NJ, Shiloh Y, Ronai Z. 2001. Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress. Mol Cell Biol 21: 27432754.
  • Buzzard KA, Giaccia AJ, Killender M, Anderson RL. 1998. Heat shock protein 72 modulates pathways of stress-induced apoptosis. J Biol Chem 273: 1714717153.
  • Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD. 1998. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281: 16771679.
  • Carballo M, Conde M, El Bekay R, Martin-Nieto J, Camacho MJ, Monteseirin J, Conde J, Bedoya FJ, Sobrino F. 1999. Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes. J Biol Chem 274: 1758017586.
  • Carpenter G, Ji Q. 1999. Phospholipase C-gamma as a signal-transducing element. Exp Cell Res 253: 1524.
  • Chakraborti S, Chakraborti T. 1998. Oxidant-mediated activation of mitogen-activated protein kinases and nuclear transcription factors in the cardiovascular system: a brief overview. Cell Signal 10: 675683.
  • Chang L, Karin M. 2001. Mammalian MAP kinase signalling cascades. Nature 410: 3740.
  • Chen YR, Tan TH. 2000. The c-Jun N-terminal kinase pathway and apoptotic signaling (review). Int J Oncol 16: 651662.
  • Chen W, Martindale JL, Holbrook NJ, Liu Y. 1998. Tumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc. Mol Cell Biol 18: 51785188.
  • Chen HC, Guh JY, Tsai JH, Lai YH. 1999. Induction of heat shock protein 70 protects mesangial cells against oxidative injury. Kidney Int 56: 12701273.
  • Chen QM, Liu J, Merrett JB. 2000. Apoptosis or senescence-like growth arrest: influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts. Biochem J 347: 543551.
  • Chen YR, Shrivastava A, Tan TH. 2001a. Down-regulation of the c-Jun N-terminal kinase (JNK) phosphatase M3/6 and activation of JNK by hydrogen peroxide and pyrrolidine dithiocarbamate. Oncogene 20: 367374.
  • Chen K, Vita JA, Berk BC, Keaney JF, Jr. 2001b. c-Jun N-terminal kinase activation by hydrogen peroxide in endothelial cells involves SRC-dependent epidermal growth factor receptor transactivation. J Biol Chem 276: 1604516050.
  • Colman MS, Afshari CA, Barrett JC. 2000. Regulation of p53 stability and activity in response to genotoxic stress. Mutat Res 462: 179188.
  • Conconi M, Petropoulos I, Emod I, Turlin E, Biville F, Friguet B. 1998. Protection from oxidative inactivation of the 20S proteasome by heat-shock protein 90. Biochem J 333 (Pt 2): 407415.
  • Cong F, Goff SP. 1999. c-Abl-induced apoptosis, but not cell cycle arrest, requires mitogen-activated protein kinase kinase 6 activation. Proc Natl Acad Sci USA 96: 1381913824.
  • Creagh EM, Cotter TG. 1999. Selective protection by hsp 70 against cytotoxic drug-, but not Fas-induced T-cell apoptosis. Immunology 97: 3644.
  • Creagh EM, Sheehan D, Cotter TG. 2000a. Heat shock proteins—modulators of apoptosis in tumour cells. Leukemia 14: 11611173.
  • Creagh EM, Carmody RJ, Cotter TG. 2000b. Heat shock protein 70 inhibits caspase-dependent and -independent apoptosis in Jurkat T cells. Exp Cell Res 257: 5866.
  • Datta SR, Brunet A, Greenberg ME. 1991. Cellular survival: a play in three Akts. Genes Dev 13: 29052927.
  • Deramaudt TB, da Silva JL, Remy P, Kappas A, Abraham NG. 1999. Negative regulation of human heme oxygenase in microvessel endothelial cells by dexamethasone. Proc Soc Exp Biol Med 222: 185193.
  • Ding Q, Keller JN. 2001. Proteasome inhibition in oxidative stress neurotoxicity: implications for heat shock proteins. J Neurochem 77: 10101017.
  • Ding J, Takano T, Gao S, Han W, Noda C, Yanagi S, Yamamura H. 2000. Syk is required for the activation of Akt survival pathway in B cells exposed to oxidative stress. J Biol Chem 275: 3087330877.
  • Drane P, Bravard A, Bouvard V, May E. 2001. Reciprocal down-regulation of p53 and SOD2 gene expression-implication in p53 mediated apoptosis. Oncogene 20: 430439.
  • Dumont A, Hehner SP, Hofmann TG, Ueffing M, Droge W, Schmitz ML. 1999. Hydrogen peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive oxygen species and the activation of NF-kappaB. Oncogene 18: 747757.
  • Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM. 2000. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J Biol Chem 275: 89458951.
  • Finkel T, Holbrook NJ. 2000. Oxidants, oxidative stress and the biology of ageing. Nature 408: 239247.
  • Flatt PM, Polyak K, Tang LJ, Scatena CD, Westfall MD, Rubinstein LA, Yu J, Kinzler KW, Vogelstein B, Hill DE, Pietenpol JA. 2000. p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest. Cancer Lett 156: 6372.
  • Flohe L, Brigelius-Flohe B, Saliou C, Traber MG, Packer L. 1997. Redox regulation of NF-kappa B activation. Free Rad Biol Med 22: 11151126.
  • Formichi P, Battisti C, Tripodi SA, Tosi P, Federico A. 2000. Apoptotic response and cell cycle transition in ataxia telangiectasia cells exposed to oxidative stress. Life Sci 66: 18931903.
  • Fuchs SY, Adler V, Pincus MR, Ronai Z. 1998. MEKK1/JNK signaling stabilizes and activates p53. Proc Natl Acad Sci USA 95: 1054110546.
  • Gabai VL, Meriin AB, Mosser DD, Caron AW, Rits S, Shifrin VI, Sherman MY. 1997. Hsp70 prevents activation of stress kinases. A novel pathway of cellular thermotolerance. J Biol Chem 272: 1803318037.
  • Gabai VL, Meriin AB, Yaglom JA, Wei JY, Mosser DD, Sherman MY. 2000a. Suppression of stress kinase JNK is involved in HSP72-mediated protection of myogenic cells from transient energy deprivation. HSP72 alleviates the stewss-induced inhibition of JNK dephosphorylation. J Biol Chem 275: 3808838094.
  • Gabai VL, Yaglom JA, Volloch V, Meriin AB, Force T, Koutroumanis M, Massie B, Mosser DD, Sherman MY. 2000b. Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death. Mol Cell Biol 20: 68266836.
  • Garay M, Gaarde W, Monia BP, Nero P, Cioffi CL. 2000. Inhibition of hypoxia/reoxygenation-induced apoptosis by an antisense oligonucleotide targeted to JNK1 in human kidney cells. Biochem Pharmacol 59: 10331043.
  • Gatei M, Shkedy D, Khanna KK, Uziel T, Shiloh Y, Pandita TK, Lavin MF, Rotman G. 2001. Ataxia-telangectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acid. Oncogene 20: 289294.
  • Ghoda L, Lin X, Greene WC. 1997. The 90-kDa ribosomal S6 kinase (pp90rsk) phosphorylates the N-terminal regulatory domain of IkappaBalpha and stimulates its degradation in vitro. J Biol Chem 272: 2128121288.
  • Gopalakrishna R, Jaken S. 2000. Protein kinase C signaling and oxidative stress. Free Rad Biol Med 28: 13491361.
  • Gorman AM, Heavey B, Creagh E, Cotter TG, Samali A. 1999. Antioxidant-mediated inhibition of the heat shock response leads to apoptosis. FEBS Lett 445: 98102.
  • Gratton JP, Morales-Ruiz M, Kureishi Y, Fulton D, Walsh K, Sessa WC. 2001. Akt down regulation of p38 signaling provides a novel mechanism of VEGF mediated cytoprotection in endothelial cells. J Biol Chem 276: 3035930365.
  • Grimberg A. 2000. P53 and IGFBP-3: apoptosis and cancer protection. Mol Genet Metab 70: 8598.
  • Guyton KZ, Gorospe M, Kensler TW, Holbrook NJ. 1996a. Mitogen-activated protein kinase (MAPK) activation by butylated hydroxytoluene hydroperoxide: implications for cellular survival and tumor promotion. Cancer Res 56: 34803485.
  • Guyton KZ, Liu Y, Gorospe M, Xu Q, Holbrook NJ. 1996b. Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury. J Biol Chem 271: 41384142.
  • Guyton KZ, Gorospe M, Wang X, Mock YD, Kokkonen GC, Liu Y, Roth GS, Holbrook NJ. 1998. Age-related changes in activation of mitogen-activated protein kinase cascades by oxidative stress. J Investig Dermatol Symp Proc 3: 2327.
  • Han H, Wang H, Long H, Nattel S, Wang Z. 2001. Oxidative preconditioning and apoptosis in l-cells. Roles of protein kinase b and mitogen-activated protein kinases. J Biol Chem 276: 2635726364.
  • Hirano M, Osada S, Aoki T, Hirai S, Hosaka M, Inoue J, Ohno S. 1996. MEK kinase is involved in tumor necrosis factor alpha-induced NF-kappaB activation and degradation of IkappaB-alpha. J Biol Chem 271: 1323413238.
  • Hirao A, Kong YY, Matsuoka S, Wakeham A, Ruland J, Yoshida H, Liu D, Elledge SJ, Mak TW. 2000. DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science 287: 18241827.
  • Hirota K, Murata M, Sachi Y, Nakamura H, Takeuchi J, Mori K, Yodoi J. 1999. Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kappaB. J Biol Chem 274: 2789127897.
  • Hollowood AD, Lai T, Perks CM, Newcomb PV, Alderson D, Holly JM. 2000. IGFBP-3 prolongs the p53 response and enhances apoptosis following UV irradiation. Int J Cancer 88: 336341.
  • Hreniuk D, Garay M, Gaarde W, Monia BP, McKay RA, Cioffi CL. 2001. Inhibition of c-Jun N-terminal kinase 1, but not c-Jun N-terminal kinase 2, suppresses apoptosis induced by ischemia/reoxygenation in rat cardiac myocytes. Mol Pharmacol 59: 867874.
  • Huang RP, Wu JX, Fan Y, Adamson ED. 1996. UV activates growth factor receptors via reactive oxygen intermediates. J Cell Biol 133: 211220.
  • Huang C, Li J, Ding M, Leonard SS, Wang L, Castranova V, Vallyathan V, Shi X. 2001. UV induces phosphorylation of protein kinase B (Akt) at Ser473 and Thr308 in mouse epidermal Cl 41 cells through hydrogen peroxide. J Biol Chem 276: 4023440240.
  • Ikeyama S, Kokkonen G, Shack S, Wang X, Holbrook NJ. 2001. Loss in oxidative stress tolerance with aging linked to reduced extracellular signal-regulated kinase and Akt kinase activities. FASEB J 16: 114116.
  • Imbert V, Rupec RA, Livolsi A, Pahl HL, Traenckner EB, Mueller-Dieckmann C, Farahifar D, Rossi B, Auberger P, Baeuerle PA, Peyron JF. 1996. Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha. Cell 86: 787798.
  • Ishikawa Y, Kitamura M. 2000. Anti-apoptotic effect of quercetin: intervention in the JNK- and ERK-mediated apoptotic pathways. Kidney Int 58: 10781087.
  • Ivanov VN, Ronai Z. 2000. p38 protects human melanoma cells from UV-induced apoptosis through down-regulation of NF-kappaB activity and Fas expression. Oncogene 19: 30033012.
  • Janssen-Heininger YM, Poynter ME, Baeuerle PA. 2000. Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB. Free Radic Biol Med 28: 13171327.
  • Jimenez LA, Zanella C, Fung H, Jansen YM, Vacek P, Charland C, Goldberg J, Mossman BT. 1997. Role of extracellular signal-regulated proetin kinases in apoptosis by asbestos and H2O2. Am J Physiol 273: L1029L1035.
  • Johnson TM, Yu ZX, Ferrans VJ, Lowenstein RA, Finkel T. 1996. Reactive oxygen species are downstream mediators of p53-dependent apoptosis. Proc Natl Acad Sci USA 93: 1184811852.
  • Jolly C, Morimoto RI. 2000. Role of the heat shock response and molecular chaperones in oncogenesis and cell death. J Natl Cancer Inst 92: 15641572.
  • Kamsler A, Daily D, Hochman A, Stern N, Shiloh Y, Rotman G, Barzilai A. 2001. Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice. Cancer Res 61: 18491854.
  • Kandel ES, Hay N. 1999. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp Cell Res 253: 210229.
  • Kannan K, Amariglio N, Rechavi G, Jakob-Hirsch J, Kela I, Kaminski N, Getz G, Domany E, Givol D. 2001. DNA microarrays identification of primary and secondary target genes regulated by p53. Oncogene 20: 22252234.
  • Kasibhatla S, Genestier L, Green DR. 1999. Regulation of fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor kappaB. J Biol Chem 274: 987992.
  • Kharbanda S, Pandey P, Yamauchi T, Kumar S, Kaneki M, Kumar V, Bharti A, Yuan ZM, Ghanem L, Rana A, Weichselbaum R, Johnson G, Kufe D. 2000. Activation of MEK kinase 1 by the c-Abl protein tyrosine kinase in response to DNA damage. Mol Cell Biol 20: 49794989.
  • Kim AH, Khursigara G, Sun X, Franke TF, Chao MV. 2001a. Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol 21: 893901.
  • Kim DK, Cho ES, Lee BR, Um HD. 2001b. NF-kappa B mediates the adaptation of human U937 cells to hydrogen peroxide. Free Radic Biol Med 30: 563571.
  • Kitamura Y, Ota T, Matsuoka Y, Tooyama I, Kimura H, Shimohama S, Nomura Y, Gebicke-Haerter PJ, Taniguchi T. 1999. Hydrogen peroxide-induced apoptosis mediated by p53 protein in glial cells. Glia 25: 154164.
  • Klotz LO, Schieke SM, Sies H, Holbrook NJ. 2000. Peroxynitrite activates the phosphoinositide 3-kinase/Akt pathway in human skin primary fibroblasts. Biochem J 352 (Pt 1): 219225.
  • Knebel A, Rahmsdorf HJ, Ullrich A, Herrlich P. 1996. Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents. EMBO J 15: 53145325.
  • Kolch W. 2000. Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem J 351 (Pt 2): 289305.
  • Komatsuda A, Wakui H, Oyama Y, Imai H, Miura AB, Itoh H, Tashima Y. 1999. Overexpression of the human 72 kDa heat shock protein in renal tubular cells confers resistance against oxidative injury and cisplatin toxicity. Nephrol Dial Transplant 14: 13851390.
  • Konishi H, Matsuzaki H, Tanaka M, Takemura Y, Kuroda S, Ono Y, Kikkawa U. 1997. Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27. FEBS Lett 410: 493498.
  • Kumar S, Bharti A, Mishra NC, Raina D, Kharbanda S, Saxena S, Kufe D. 2001. Targeting of the c-Abl tyrosine kinase to mitochondria in the necrotic cell death response to oxidative stress. J Biol Chem 276: 1728117285.
  • Kurata S. 2000. Selective activation of p38 MAPK cascade and mitotic arrest caused by low level oxidative stress. J Biol Chem 275: 2341323416.
  • Kyriakis JM, Avruch J. 2001. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81: 807869.
  • Lavin MF, Shiloh Y. 1997. The genetic defect in ataxia-telangiectasia. Annu Rev Immunol 15: 177202.
  • Lee SR, Kwon KS, Kim SR, Rhee SG. 1998. Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor. J Biol Chem 273: 1536615372.
  • Lee YH, Kim S, Kim J, Young KK, Kim MJ, Ryu SH, Suh P. 1999. Overexpression of phospholipase C-gamma1 suppresses UVC-induced apoptosis through inhibition of c-fos accumulation and c-Jun N-terminal kinase activation in PC12 cells. Biochim Biophys Acta 1440: 235243.
  • Lee YH, Kim SY, Kim JR, Yoh KT, Baek SH, Kim MJ, Ryu SH, Suh PG, Kim JH. 2000a. Overexpression of phospholipase Cbeta-1 protects NIH3T3 cells from oxidative stress-induced cell death. Life Sci 67: 827837.
  • Lee SW, Fang L, Igarashi M, Ouchi T, Lu KP, Aaronson SA. 2000b. Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53. Proc Natl Acad Sci USA 97: 83028305.
  • Li N, Karin M. 1999. Is NF-kappaB the sensor of oxidative stress? FASEB J 13: 11371143.
  • Li PF, Maasch C, Haller H, Dietz R, von Harsdorf R. 1999. Requirement for protein kinase C in reactive oxygen species-induced apoptosis of vascular smooth muscle cells. Circulation 100: 967973.
  • Lin Y, Ma W, Benchimol S. 2000. Pidd, a mew death-domain-containing protein, is induced by p53 and promotes apoptosis. Nat Genet 26: 122127.
  • Lithgow GJ, Andersen JK. 2000. The real Dorian Gray mouse. Bioessays 22: 410413.
  • Livolsi A, Busuttil V, Imbert V, Abraham RT, Peyron JF. 2001. Tyrosine phosphorylation-dependent activation of NF-kappa B. Requirement for p56 LCK and ZAP-70 protein tyrosine kinases. Eur J Biochem 268: 15081515.
  • Luo Y, Umegaki H, Wang X, Abe R, Roth GS. 1998. Dopamine induces apoptosis through an oxidation-involved SAPK/JNK activation pathway. J Biol Chem 273: 37563764.
  • Luo Y, Hattori A, Munoz J, Qin ZH, Roth GS. 1999. Intrastriatal dopamine injection induces apoptosis through oxidation-involved activation of transcription factors AP-1 and NF-kappaB in rats. Mol Pharmacol 56: 254264.
  • Madamanchi NR, Li S, Patterson C, Runge MS. 2001. Reactive oxygen species regulate heat-shock protein 70 via the JAK/STAT pathway. Arterioscler Thromb Vasc Biol 21: 321326.
  • Madrid LV, Mayo MW, Reuther JY, Baldwin AS, Jr. 2001. Akt stimulates the transactivation potential of the RelA/p65 subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38. J Biol Chem 276: 1893418940.
  • Maher P. 2001. How protein kinase C activation protects nerve cells from oxidative stress-induced cell death. J Neurosci 21: 29292938.
  • Majumder PK, Mishra NC, Sun X, Bharti A, Kharbanda S, Saxena S, Kufe D. 2001. Targeting of protein kinase C δ to mitochondria in the oxidative stress response. Cell Growth Differ 12: 465470.
  • Marini M, Frabetti F, Musiani D, Franceschi C. 1996. Oxygen radicals induce stress proteins and tolerance to oxidative stress in human lymphocytes. Int J Radiat Biol 70: 337350.
  • Matsui K, Fine A, Zhu B, Marshak-Rothstein A, Ju ST. 1998. Identification of two NF-kappa B sites in mouse CD95 ligand (Fas ligand) promoter: functional analysis in T cell hybridoma. J Immunol 161: 34693473.
  • Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ. 2000. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc Natl Acad Sci USA 97: 1038910394.
  • Mattson MP, Goodman Y, Luo H, Fu W, Furukawa K. 1997. Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration. J Neurosci Res 49: 681697.
  • Mattson MP, Culmsee C, Yu Z, Camandola S. 2000. Roles of nuclear factor kappaB in neuronal survival and plasticity. J Neurochem 74: 443456.
  • Meier R, Hemmings BA. 1999. Regulation of protein kinase B. J Recept Signal Transduct Res 19: 121128.
  • Meier R, Thelen M, Hemmings BA. 1998. Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha) promoted by hyperosmotic stress. EMBO J 17: 72947303.
  • Meplan C, Richard MJ, Hainaut P. 2000. Redox signalling and transition metals in the control of the p53 pathway. Biochem Pharmacol 59: 2533.
  • Meriin AB, Yaglom JA, Gabai VL, Zon L, Ganiatsas S, Mosser DD, Zon L, Sherman MY. 1999. Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: a novel pathway controlled by HSP72. Mol Cell Biol 19: 25472555.
  • Meves A, Stock SN, Beyerle A, Pittelkow MR, Peus D. 2001. H2O2 mediates oxidative stress-induced epidermal growth factor receptor phosphorylation. Toxicol Lett 122: 205214.
  • Meyer CF, Wang X, Chang C, Templeton D, Tan TH. 1996. Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activation. J Biol Chem 271: 89718976.
  • Migliaccio E, Mele S, Salcini AE, Pelicci G, Lai KM, Superti-Furga G, Pawson T, Di Fiore PP, Lanfrancone L, Pelicci PG. 1997. Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. EMBO J 16: 706716.
  • Migliaccio E, Giorgio M, Mele S, Pelicci G, Reboldi P, Pandolfi PP, Lanfrancone L, Pelicci PG. 1999. The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 402: 309313.
  • Minamino T, Yujiri T, Papst PJ, Chan ED, Johnson GL, Terada N. 1999. MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes. Proc Natl Acad Sci USA 96: 1512715132.
  • Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, Hoffman B, Reed JC. 1994. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9: 17991805.
  • Mosser DD, Caron AW, Bourget L, Denis-Larose C, Massie B. 1997. Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis. Mol Cell Biol 17: 53175327.
  • Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, Massie B. 2000. The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol 20: 71467159.
  • Nakano K, Vousden KH. 2001. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 7: 683694.
  • Nemoto S, Xiang J, Huang S, Lin A. 1998. Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase. J Biol Chem 273: 1641516420.
  • Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N. 2000a. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288: 10531058.
  • Oda K, Arakawa H, Tanaka T, Matsuda K, Tanikawa C, Mori T, Nishimori H, Tamai K, Tokino T, Nakamura Y, Taya Y. 2000b. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell 102: 849862.
  • Pahl HL. 1999. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 18: 68536866.
  • Pani G, Bedogni B, Anzevino R, Colavitti R, Palazzotti B, Borrello S, Galeotti T. 2000. Deregulated manganese superoxide dismutase expression and resistance to oxidative injury in p53-deficient cells. Cancer Res 60: 46544660.
  • Park YM, Han MY, Blackburn RV, Lee YJ. 1998. Overexpression of HSP25 reduces the level of TNF alpha-induced oxidative DNA damage biomarker, 8-hydroxy-2′-deoxyguanosine, in L929 cells. J Cell Physiol 174: 2734.
  • Park HS, Lee JS, Huh SH, Seo JS, Choi EJ. 2001a. Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase. EMBO J 20: 446456.
  • Park SK, Kim J, Seomun Y, Choi J, Kim DH, Han IO, Lee EH, Chung SK, Joo CK. 2001b. Hydrogen peroxide is a novel inducer of connective tissue growth factor. Biochem Biophys Res Commun 284: 966971.
  • Petrache I, Choi ME, Otterbein LE, Chin BY, Mantell LL, Horowitz S, Choi AM. 1999. Mitogen-activated protein kinase pathway mediates hyperoxia-induced apoptosis in cultured macrophage cells. Am J Physiol 277: L589L595.
  • Peus D, Pittelkow MR. 2001. Reactive oxygen species as mediators of UVB-induced mitogen-activated protein kinase activation in keratinocytes. Curr Probl Dermatol 29: 114127.
  • Pirkkala L, Nykanen P, Sistonen L. 2001. Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. FASEB J 15: 11181131.
  • Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B. 1997. A model for p53-induced apoptosis. Nature 389: 300305.
  • Potapova O, Haghighi A, Bost F, Liu C, Birrer MJ, Gjerset R, Mercola D. 1997. The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin. J Biol Chem 272: 1404114044.
  • Potapova O, Basu S, Mercola D, Holbrook NJ. 2001. Protective role for c-Jun in the cellular response to DNA damage. J Biol Chem 276: 2854628553.
  • Preville X, Schultz H, Knauf U, Gaestel M, Arrigo AP. 1998. Analysis of the role of Hsp25 phosphorylation reveals the importance of the oligomerization state of this small heat shock protein in its protective function against TNFalpha- and hydrogen peroxide-induced cell death. J Cell Biochem 69: 436452.
  • Preville X, Salvemini F, Giraud S, Chaufour S, Paul C, Stepien G, Ursini MV, Arrigo AP. 1999. Mammalian small stress proteins protect against oxidative stress through their ability to increase glucose-6-phosphate dehydrogenase activity and by maintaining optimal cellular detoxifying machinery. Exp Cell Res 247: 6178.
  • Qin S, Inazu T, Yamamura H. 1995. Activation and tyrosine phosphorylation of p72syk as well as calcium mobilization after hydrogen peroxide stimulation in peripheral blood lymphocytes. Biochem J 308 (Pt 1): 347352.
  • Rane SG, Reddy EP. 2000. Janus kinases: components of multiple signaling pathways. Oncogene 19: 56625679.
  • Rhee SG, Bae YS. 1997. Regulation of phosphoinositide-specific phospholipase C isozymes. J Biol Chem 272: 1504515048.
  • Rotman G, Shiloh Y. 1997. Ataxia-telangiectasia: is ATM a sensor of oxidative damage and stress? Bioessays 19: 911917.
  • Ryan KM, Ernst MK, Rice NR, Vousden KH. 2000. Role of NF-kappaB in p53-mediated programmed cell death. Nature 404: 892897.
  • Sachsenmaier C, Radler-Pohl A, Zinck R, Nordheim A, Herrlich P, Rahmsdorf HJ. 1994. Involvement of growth factor receptors in the mammalian UVC response. Cell 78: 963972.
  • Saitoh M, Nishitoh H, Fujii M, Takeda K, Tobiume K, Sawada Y, Kawabata M, Miyazono K, Ichijo H. 1998. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J 17: 25962606.
  • Salinas M, Martin D, Alvarez A, Cuadrado A. 2001. Akt1/PKBalpha protects PC12 cells against the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium and reduces the levels of oxygen-free radicals. Mol Cell Neurosci 17: 6777.
  • Schieven GL, Kirihara JM, Myers DE, Ledbetter JA, Uckun FM. 1993. Reactive oxygen intermediates activated NF-kappa B in a tyrosine kinase-dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes. Blood 82: 12121220.
  • Schieven GL, Mittler RS, Nadler SG, Kirihara JM, Bolen JB, Kanner SB, Ledbetter JA. 1994. ZAP-70 tyrosine kinase, CD45, and T cell receptor involvement in UV- and H2O2-induced T cell signal transduction. J Biol Chem 269: 2071820726.
  • Schmidt KN, Amstad P, Cerutti P, Baeuerle PA. 1995. The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-kappa B. Chem Biol 2: 1322.
  • Schmidt KN, Amstad P, Cerutti P, Baeuerle PA. 1996. Identification of hydrogen peroxide as the relevant messenger in the activation pathway of transcription factor NF-kappaB. Adv Exp Med Biol 387: 6368.
  • Schoonbroodt S, Piette J. 2000. Oxidative stress interference with the nuclear factor-kappa B activation pathways. Biochem Pharmacol 60: 10751083.
  • Schoonbroodt S, Ferreira V, Best-Belpomme M, Boelaert JR, Legrand-Poels S, Korner M, Piette J. 2000. Crucial role of the amino-terminal tyrosine residue 42 and the carboxyl-terminal PEST domain of I kappa B alpha in NF-kappa B activation by an oxidative stress. J Immunol 164: 42924300.
  • Schreck R, Rieber P, Baeuerle PA. 1991. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J 10: 22472258.
  • Sha WC. 1998. Regulation of immune responses by NF-kappa B/Rel transcription factor. J Exp Med 187: 143146.
  • Shackelford RE, Innes CL, Sieber SO, Heinloth AN, Leadon SA, Paules RS. 2001. The ataxia telangiectasia gene product is required for oxidative stress-induced G1 and G2 checkpoint function in human fibroblasts. J Biol Chem 276: 2195121959.
  • Shaulian E, Schreiber M, Piu F, Beeche M, Wagner EF, Karin M. 2000. The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest. Cell 103: 897907.
  • Shiloh Y. 2001. ATM and ATR: networking cellular responses to DNA damage. Curr Opin Genet Dev 11: 7177.
  • Shimizu H, Banno Y, Sumi N, Naganawa T, Kitajima Y, Nozawa Y. 1999. Activation of p38 mitogen-activated protein kinase and caspases in UVB-induced apoptosis of human keratinocyte HaCaT cells. J Invest Dermatol 112: 769774.
  • Shou Y, Gunasekar PG, Borowitz JL, Isom GE. 2000. Cyanide-induced apoptosis involves oxidative-stress-activated NF-kappaB in cortical neurons. Toxicol Appl Pharmacol 164: 196205.
  • Simon AR, Rai U, Fanburg BL, Cochran BH. 1998. Activation of the JAK-STAT pathway by reactive oxygen species. Am J Physiol 275: C1640C1652.
  • Sionov RV, Haupt Y. 1999. The cellular response to p53: the decision between life and death. Oncogene 18: 61456157.
  • Skulachev VP. 2000. The p66shc protein: a mediator of the programmed death of an organism? IUBMB Life 49: 177180.
  • Sonoda Y, Watanabe S, Matsumoto Y, Aizu-Yokota E, Kasahara T. 1999. FAK is the upstream signal protein of the phosphatidylinositol 3-kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human glioblastoma cell line. J Biol Chem 274: 1056610570.
  • Su CY, Chong KY, Edelstein K, Lille S, Khardori R, Lai CC. 1999. Constitutive hsp70 attenuates hydrogen peroxide-induced membrane lipid peroxidation. Biochem Biophys Res Commun 265: 279284.
  • Sun X, Majumder P, Shioya H, Wu F, Kumar S, Weichselbaum R, Kharbanda S, Kufe D. 2000a. Activation of the cytoplasmic c-Abl tyrosine kinase by reactive oxygen species. J Biol Chem 275: 1723717240.
  • Sun X, Wu F, Datta R, Kharbanda S, Kufe D. 2000b. Interaction between protein kinase C delta and the c-Abl tyrosine kinase in the cellular response to oxidative stress. J Biol Chem 275: 74707473.
  • Takao N, Li Y, Yamamoto K. 2000. Protective roles for ATM in cellular response to oxidative stress. FEBS Lett 472: 133136.
  • Tan M, Li S, Swaroop M, Guan K, Oberley LW, Sun Y. 1999. Transcriptional activation of the human glutathione peroxidase promoter by p53. J Biol Chem 274: 1206112066.
  • Taylor WR, Stark GR. 2001. Regulation of the G2/M transition by p53. Oncogene 20: 18031815.
  • Thannickal VJ, Fanburg BL. 2000. Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol 279: L1005L1028.
  • Tobiume K, Matsuzawa A, Takahashi T, Nishitoh H, Morita K, Takeda K, Minowa O, Miyazono K, Noda T, Ichijo H. 2001. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep 2: 222228.
  • Tournier C, Hess P, Yang DD, Xu J, Turner TK, Nimnual A, Bar-Sagi D, Jones SN, Flavell RA, Davis RJ. 2000. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 288: 870874.
  • Tournier C, Dong C, Turner TK, Jones SN, Flavell RA, Davis RJ. 2001. MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. Genes Dev 15: 14191426.
  • Turner NA, Xia F, Azhar G, Zhang X, Liu L, Wei JY. 1998. Oxidative stress induces DNA fragmentation and caspase activation via the c-Jun NH2-terminal kinase pathway in H9c2 cardiac muscle cells. J Mol Cell Cardiol 30: 17891801.
  • Vollgraf U, Wegner M, Richter-Landsberg C. 1999. Activation of AP-1 and nuclear factor-kappaB transcription factors is involved in hydrogen peroxide-induced apoptotic cell death of oligodendrocytes. J Neurochem 73: 25012509.
  • Volloch V, Gabai VL, Rits S, Force T, Sherman MY. 2000. HSP72 can protect cells from heat-induced apoptosis by accelerating the inactivation of stress kinase JNK. Cell Stress Chaperones 5: 139147.
  • Wang X, Martindale JL, Liu Y, Holbrook NJ. 1998. The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival. Biochem J 333 (Pt 2): 291300.
  • Wang X, Martindale JL, Holbrook NJ. 2000a. Requirement for ERK activation in cisplatin-induced apoptosis. J Biol Chem 275: 3943539443.
  • Wang X, McCullough KD, Franke TF, Holbrook NJ. 2000b. Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival. J Biol Chem 275: 1462414631.
  • Wang X, McCullough KD, Wang XJ, Carpenter G, Holbrook NJ. 2001. Oxidative stress-induced phospholipase C-g1 activation enhances cell survival. J Biol Chem 246: 2836428371.
  • Wong HR, Menendez IY, Ryan MA, Denenberg AG, Wispe JR. 1998. Increased expression of heat shock protein-70 protects A549 cells against hyperoxia. Am J Physiol 275: L836L841.
  • Wu H, Lozano G. 1994. NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress. J Biol Chem 269: 2006720074.
  • Wu GS, Kim K, El Deiry WS. 2000. KILLER/DR5, a novel DNA-damage inducible death receptor gene, links the p53-tumor suppressor to caspase activation and apoptotic death. Adv Exp Med Biol 465: 143151.
  • Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. 1995. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 13261331.
  • Xie S, Wang Q, Wu H, Cogswell J, Lu L, Jhanwar-Uniyal M, Dai W. 2001. Reactive oxygen species induced-phosphorylation of p53 on serine-20 is mediated in part by Plk3. J Biol Chem 276: 3619436199.
  • Yamamoto H, Yamamoto Y, Yamagami K, Kume M, Kimoto S, Toyokuni S, Uchida K, Fukumoto M, Yamaoka Y. 2000. Heat-shock preconditioning reduces oxidative protein denaturation and ameliorates liver injury by carbon tetrachloride in rats. Res Exp Med (Berl) 199: 309318.
  • Yin Y, Terauchi Y, Solomon GG, Aizawa S, Rangarajan PN, Yazaki Y, Kadowaki T, Barrett JC. 1998. Involvement of p85 in p53-dependent apoptotic response to oxidative stress. Nature 391: 707710.
  • Yin Z, Ivanov VN, Habelhah H, Tew K, Ronai Z. 2000. Glutathione S-transferase p elicits protection against H2O2-induced cell death via coordinated regulation of stress kinases. Cancer Res 60: 40534057.
  • Yu Z, Zhou D, Cheng G, Mattson MP. 2000. Neuroprotective role for the p50 subunit of NF-kappaB in an experimental model of Huntington's disease. J Mol Neurosci 15: 3144.
  • Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B. 2001. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 7: 673682.
  • Zanella CL, Posada J, Tritton TR, Mossman BT. 1996. Asbestos causes stimulation of the extracellular-regulated kinase 1 mitogen-activated protein kinase cascade after phophorylation of the epidermal growth factor receptor. Cancer Res 56: 53345338.
  • Zanke BW, Boudreau K, Rubie E, Winnett E, Tibbles LA, Zon L, Kyriakis J, Liu FF, Woodgett JR. 1996. The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat. Curr Biol 6: 606613.
  • Zhang J, Johnston G, Stebler B, Keller ET. 2001. Hydrogen peroxide activates NFkappaB and the interleukin-6 promoter through NFkappaB-inducing kinase. Antioxid Redox Signal 3: 493504.
  • Zhou H, Summer SA, Birnbaum MJ, Pittman RN. 1998. Inhibition of Akt kinase by cell-permeable ceramide and its implication for ceramide-induced apoptosis. J Biol Chem 273: 1656816575.
  • Zhuang S, Demirs JT, Kochevar IE. 2000. p38 mitogen-activated protein kinase mediates bid cleavage, mitochondrial dysfunction, and caspase-3 activation during apoptosis induced by singlet oxygen but not by hydrogen peroxide. J Biol Chem 275: 2593925948.
  • Zou X, Tsutsui T, Ray D, Blomquist JF, Ichijo H, Ucker DS, Kiyokawa H. 2001. The cell cycle-regulatory CDC25A phosphatase inhibits apoptosis signal-regulating kinase 1. Mol Cell Biol 21: 48184828.
  • Zundel W, Giaccia A. 1998. Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress. Genes Dev 12: 19411946.