Hypoxia is a major stimulator of osteoclast formation and bone resorption
Article first published online: 5 MAY 2003
Copyright © 2003 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 196, Issue 1, pages 2–8, July 2003
How to Cite
Arnett, T. R., Gibbons, D. C., Utting, J. C., Orriss, I. R., Hoebertz, A., Rosendaal, M. and Meghji, S. (2003), Hypoxia is a major stimulator of osteoclast formation and bone resorption. J. Cell. Physiol., 196: 2–8. doi: 10.1002/jcp.10321
- Issue published online: 19 MAY 2003
- Article first published online: 5 MAY 2003
- Manuscript Accepted: 28 MAR 2003
- Manuscript Received: 5 FEB 2003
- Arthritis Research Campaign
- 2001. Hypoxia induces vascular endothelial growth factor gene transcription in human osteoblast-like cells through the hypoxia-inducible factor-2α. Endocrinology 142: 959–962. , , , .
- 2002. Induction of vascular endothelial growth factor by IGF-I in osteoblast-like cells is mediated by the PI3K signaling pathway through the hypoxia-inducible factor-2α. Endocrinology 143: 420–425. , , , , .
- 1986. Effect of pH on bone resorption by rat osteoclasts in vitro. Endocrinology 119: 119–124. , .
- 1987. A comparative study of disaggregated chick and rat osteoclasts in vitro: Effects of calcitonin and prostaglandins. Endocrinology 120: 602–608. , .
- 1996. Modulation of the resorptive activity of rat osteoclasts by small changes in extracellular pH near the physiological range. Bone 18: 277–279. , .
- 2003. Hypoxia is a major stimulator of osteoclast formation from human peripheral blood. Calcified Tissue Int 72: 345 (abstract). , , , , .
- 1995. Synergistic effect of acute hypoxia on flow-induced release of ATP from cultured endothelial cells. Experientia 51: 256–259. , .
- 1978. The effect of oxygen tension on haemopoietic and fibroblast cell proliferation in vitro. J Cell Physiol 97: 517–522. , , .
- 1996. Blood supply to the human femoral diaphysis in youth and senescence. J Anat 188: 611–621. , .
- 1998. The blood supply of bone: Scientific aspects. London: Springer .
- 1990. Enhanced stimulation of human bone marrow macrophage colony formation in vitro by recombinant human macrophage colony-stimulating factor in agarose medium and at low oxygen tension. Blood 76: 323–329. , , , , , .
- 2001. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294: 1337–1340. , .
- 2001. Modeling pO2 distributions in the bone marrow hematopoietic compartment. I. Krogh's model; II. Modified Kroghian models. Biophys J 81: 675–684 & 685–696. , , , .
- 1992. Prostaglandin E2 promotes osteoclast formation in murine hematopoietic cultures through an action on hematopoietic cells. J Bone Miner Res 7: 555–561. , .
- 1999. Osteocyte hypoxia: A novel mechanotransduction pathway. Am J Physiol 277: C598–C602. , , .
- 1999. Hypoxemia is a risk factor for bone mass loss. J Bone Miner Metab 17: 211–216. , , , .
- 2000. A role for TGFβ1 in osteoclast differentiation and survival. J Cell Sci 113: 2445–2453. , , , , .
- 2001. Osteocytes upregulate HIF-1α in response to acute disuse and oxygen deprivation. J Appl Physiol 90: 2514–2519. , , , , , , .
- 2002. Oxygen saturation in the bone marrow of healthy volunteers. Blood 99: 394. , , , .
- 1995. Osteoblasts mediate insulin-like growth factor-I and -II stimulation of osteoclast formation and function. Endocrinology 136: 124–131. , , .
- 2003. Isolated osteoclast cultures. In: RalstonSH, HelfrichMH, editors. Bone research protocols. Totoma, New Jersey: Humana Press. p 53–64. , .
- 2000. Expression of P2 receptors in bone and cultured bone cells. Bone 27: 503–510. , , , .
- 2001. Extracellular ADP is a powerful osteolytic agent: evidence for signaling through the P2Y1 receptor on bone cells. FASEB J 15: 1139–1148. , , , .
- 1988. Kinetics of hemopoietic stem cells in a hypoxic culture. Eur J Haematol 40: 126–129. , .
- 2001. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292: 468–472. , , , , , , , , , , , , .
- 1992. Reduced oxygen tension increases hematopoiesis in long-term culture of human stem and progenitor cells from cord blood and bone marrow. Exp Hematol 20: 264–270. , , , .
- 1998. Prostaglandin E2, interleukin 1α, and tumor necrosis factor-α increase human osteoclast formation and bone resorption in vitro. Endocrinology 139: 3157–3164. , .
- 2001. Cultivation of rat marrow-derived mesenchymal stem cells in reduced O2 tension: Effects on in vitro and in vivo osteochondrogenesis. J Cell Physiol 187: 345–355. , , .
- 1999. Macrophage responses to hypoxia: Relevance to disease mechanisms. J Leukocyte Biol 66: 889–900. , , , , .
- 1994. Non-invasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy. Cancer Res 54: 5670–5674. , .
- 2001. Transforming growth factor-beta1 (TGF-beta) stimulates the osteoclast-forming potential of peripheral blood hematopoietic precursors in a lymphocyte-rich microenvironment. Bone 28: 577–582. , , , .
- 1998. Proliferation and differentiation of human osteoblastic cells associated with differential activation of MAP kinases in response to epidermal growth factor, hypoxia, and mechanical stress in vitro. Biochem Biophys Res Commun 249: 350–354. , , , .
- 2001. pH dependence of bone resorption: Mouse calvarial osteoclasts are activated by acidosis. Am J Physiol 280: E112–E119. , , , .
- 1998. ATP is a potent stimulator of the activation and formation of rodent osteoclasts. J Physiol 511: 495–500. , , , , .
- 1999. Basic fibroblast growth factor induces osteoclast formation by reciprocally regulating the production of osteoclast differentiation factor and osteoclastogenesis inhibitory factor in mouse osteoblastic cells. Biochem Biophys Res Commun 265: 158–163. , , , , , , , , , , .
- 2000. Vascular endothelial growth factor (VEGF) directly enhances osteoclastic bone resorption and survival of mature osteoclasts. FEBS Lett 473: 161–164. , , , , , , , , .
- 2001. Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival. Genes Dev 15: 2865–2876. , , , , , .
- 1997. Chondrocytes in the endochondral growth cartilage are not hypoxic. Am J Physiol 272: C1134–C1143. , , , , .
- 1991. Effects of acid and basic fibroblast growth factor and heparin on resorption of cultured fetal rat long bones. J Bone Miner Res 6: 1301–1305. , .
- 1999. Hypoxia regulates VEGF expression and cellular proliferation by osteoblasts in vitro. Plast Reconstr Surg 104: 738–747. , , , , , , , .
- 2000a. VEGF expression in an osteoblast-like cell line is regulated by a hypoxia response mechanism. Am J Physiol 278: C853–C860. , , , , , , .
- 2000b. Hypoxia increases insulinlike growth factor gene expression in rat osteoblasts. Ann Plast Surg 44: 529–535. , , , , , , .
- 1966. The effect of various oxygen tensions on the synthesis and degradation of bone collagen in tissue culture. Proc Soc Exp Biol Med 121: 869–872. , , .
- 2001. The molecular basis of osteoclast differentiation and activation. Novartis Found Symp 232: 235–247. , , , , .
- 1994. Oxygen tension regulates osteoblast function. Am J Orthod Dentofacial Orthop 105: 457–463. , , .
- 2001. Hypoxia regulates osteoblast gene expression. J Surg Res 99: 147–155. , , , , , , , .