Nature of permeability changes in membrane of HeLa cells adsorbing sendai virus
Article first published online: 4 FEB 2005
Copyright © 1980 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 103, Issue 2, pages 271–278, May 1980
How to Cite
Fuchs, P., Gruber, E., Gitelman, J. and Kohn, A. (1980), Nature of permeability changes in membrane of HeLa cells adsorbing sendai virus. J. Cell. Physiol., 103: 271–278. doi: 10.1002/jcp.1041030212
- Issue published online: 4 FEB 2005
- Article first published online: 4 FEB 2005
- Manuscript Accepted: 19 DEC 1979
- Manuscript Received: 17 AUG 1979
Adsorption of Sendai virus to HeLa cells induced in them an increased permeability to K+, Na+, Ca++, deoxyglucose, but not to fluorescein. The stimulation of uptake of 42K was temperature-dependent, did not occur below 15°C, and was not inhibited by ouabain.
The virus-induced increase in the uptake and release of 42K and of 3H deoxyglucose could not be mimicked by treatment of cells with linoleic acid, a procedure which increased the fluidity of the cellular membranes. The stimulatory effect of 0.5 mM ATP on the release of deoxyglucose was enhanced several fold in the presence of Sendai virus. These results seem to indicate the possible involvement of membranal enzymes such as e.g. protein kinase in the permeability changes induced by Sendai virus.