Interleukin-1 is a potent regulator of JE and KC gene expression in quiescent BALB/c fibroblasts
Version of Record online: 4 FEB 2005
Copyright © 1989 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 141, Issue 1, pages 154–159, October 1989
How to Cite
Hall, D. J., Brownlee, C. and Stiles, C. D. (1989), Interleukin-1 is a potent regulator of JE and KC gene expression in quiescent BALB/c fibroblasts. J. Cell. Physiol., 141: 154–159. doi: 10.1002/jcp.1041410123
- Issue online: 4 FEB 2005
- Version of Record online: 4 FEB 2005
- Manuscript Accepted: 30 MAY 1989
- Manuscript Received: 17 JAN 1989
Interleukin-1 alpha and beta are polypeptide hormones with a broad range of biological activities. Both interleukins are recognized by a receptor that has been characterized as a member of the immunoglobin superfamily. The interleukin-1 receptor does not appear to be a tyrosine protein kinase. Moreover, the intracellular events that mediate the multiple interleukin-1 responses are poorly understood. Here we show that the JE and KC genes, first isolated and characterized as platelet-derived growth factor inducible in quiescent BALB/c-3T3 fibroblasts, are induced by femtomolar concentrations of recombinant interleukin-1 alpha (rlL-1). The response of JE and KC to IL-1 occurs at the transcriptional level. These observations suggest that an analysis of the JE and KC transcriptional response to rlL-1 may aid in identifying elements involved in interleukin-1-mediated signal transduction.