Nitric oxide chemistry and cellular signaling
Article first published online: 5 APR 2001
Copyright © 2001 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 187, Issue 3, pages 277–282, June 2001
How to Cite
Gow, A. J. and Ischiropoulos, H. (2001), Nitric oxide chemistry and cellular signaling. J. Cell. Physiol., 187: 277–282. doi: 10.1002/jcp.1085
- Issue published online: 18 APR 2001
- Article first published online: 5 APR 2001
- Manuscript Received: 22 JAN 2001
- Manuscript Accepted: 22 JAN 2001
Nitric oxide (NO) has been shown to mediate a number of different physiological functions within every major organ system. This wide variety of functional roles is made all the more remarkable when one considers that NO is a simple diatomic molecule. However, despite the simplicity of the molecule, NO possesses a wide range of chemical reactivity and multiple potential reactive targets. It is the variability of NO reactivity, which leads to its capability to control such a vast range of biological functions. In essence the functionality of NO is controlled by its chemical reactivity. In order to understand this possibility further it is necessary to consider the biologically relevant reactions of nitric oxide. © 2001 Wiley-Liss, Inc.