Emerging non-apoptotic functions of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/Apo2L
Article first published online: 7 JUN 2004
Copyright © 2004 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 201, Issue 3, pages 331–340, December 2004
How to Cite
Pietro, R. D. and Zauli, G. (2004), Emerging non-apoptotic functions of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/Apo2L. J. Cell. Physiol., 201: 331–340. doi: 10.1002/jcp.20099
- Issue published online: 29 SEP 2004
- Article first published online: 7 JUN 2004
- Manuscript Accepted: 6 JAN 2004
- Manuscript Received: 9 DEC 2003
- 2001 MIUR COFIN
Tumor necrosis factor (TNF) is a cytokine that mediates tumor necrosis. To date, 20 different members of the TNF super-family and 21 different receptors have been identified. All ligands of the TNF super-family have been found to activate transcription factor NF-κB and c-Jun kinase. Members of this family have diverse biological effects, including induction of apoptosis, promotion of cell survival, and regulation of the immune system and hematopoiesis. The current review focuses on the biological effects of TNF-related apoptosis-inducing ligand (TRAIL), a TNF super-family member which, a few years ago, generated considerable enthusiasm for its anticancer activity, not accompanied by general toxicity in most normal tissues and organs. © 2004 Wiley-Liss, Inc.