Laminopathies: Involvement of structural nuclear proteins in the pathogenesis of an increasing number of human diseases
Article first published online: 23 SEP 2004
Copyright © 2004 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 203, Issue 2, pages 319–327, May 2005
How to Cite
Maraldi, N. M., Squarzoni, S., Sabatelli, P., Capanni, C., Mattioli, E., Ognibene, A. and Lattanzi, G. (2005), Laminopathies: Involvement of structural nuclear proteins in the pathogenesis of an increasing number of human diseases. J. Cell. Physiol., 203: 319–327. doi: 10.1002/jcp.20217
- Issue published online: 23 FEB 2005
- Article first published online: 23 SEP 2004
- Manuscript Accepted: 2 AUG 2004
- Manuscript Received: 15 MAY 2004
- Italian Health Ministry. Grant Number: P.F. 83/2001
- Italian Ministry for University and Research (FIRB Project). Grant Number: RBNE01JJ45_005
- Fondazione Carisbo; Programma CNR/MUIR-Legge 449/97
Just at the beginning of the millennium the neologism laminopathies has been introduced in the scientific vocabulary. An exponential increase of interest on the subject started concomitantly, so that a formerly quite neglected group of rare human diseases is now widely investigated. This review will cover the history of the identification of the molecular basis for fourteen (since now) hereditary diseases arising from defects in genes that encode nuclear envelope and nuclear lamina-associated proteins and will also consider the hypotheses that can account for the role of structural nuclear proteins in the pathogenesis of diseases affecting a wide spectrum of tissues. © 2004 Wiley-Liss, Inc.