Smart materials as scaffolds for tissue engineering

Authors

  • Francesco Rosso,

    1. IX Division of General Surgery and Applied Biotechnology, Department of Anaesthesological, Surgical and Emergency Sciences, Second University of Naples, Italy
    Search for more papers by this author
  • Gerardo Marino,

    1. IX Division of General Surgery and Applied Biotechnology, Department of Anaesthesological, Surgical and Emergency Sciences, Second University of Naples, Italy
    Search for more papers by this author
  • Antonio Giordano,

    1. IX Division of General Surgery and Applied Biotechnology, Department of Anaesthesological, Surgical and Emergency Sciences, Second University of Naples, Italy
    Search for more papers by this author
  • Manlio Barbarisi,

    1. IX Division of General Surgery and Applied Biotechnology, Department of Anaesthesological, Surgical and Emergency Sciences, Second University of Naples, Italy
    Search for more papers by this author
  • Domenico Parmeggiani,

    1. IX Division of General Surgery and Applied Biotechnology, Department of Anaesthesological, Surgical and Emergency Sciences, Second University of Naples, Italy
    Search for more papers by this author
  • Alfonso Barbarisi

    Corresponding author
    1. IX Division of General Surgery and Applied Biotechnology, Department of Anaesthesological, Surgical and Emergency Sciences, Second University of Naples, Italy
    • Department of Anaesthesological, Surgical and Emergency Sciences, Second University of Naples, Italy, Piazza Miraglia, I-80138 Naples, Italy.
    Search for more papers by this author

Abstract

In this review, we focused our attention on the more important natural extracellular matrix (ECM) molecules (collagen and fibrin), employed as cellular scaffolds for tissue engineering and on a class of semi-synthetic materials made from the fusion of specific oligopeptide sequences, showing biological activities, with synthetic materials. In particular, these new “intelligent” scaffolds may contain oligopeptide cleaving sequences specific for matrix metalloproteinases (MMPs), integrin binding domains, growth factors, anti-thrombin sequences, plasmin degradation sites, and morphogenetic proteins. The aim was to confer to these new “intelligent” semi-synthetic biomaterials, the advantages offered by both the synthetic materials (processability, mechanical strength) and by the natural materials (specific cell recognition, cellular invasion, and the ability to supply differentiation/proliferation signals). Due to their characteristics, these semi-synthetic biomaterials represent a new and versatile class of biomimetic hybrid materials that hold clinical promise in serving as implants to promote wound healing and tissue regeneration. © 2005 Wiley-Liss, Inc.

Ancillary