Francisco J. Blanco and Juan F. Santibanez contributed equally to this work.
Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-β receptor complex†
Article first published online: 8 FEB 2005
Copyright © 2005 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 204, Issue 2, pages 574–584, August 2005
How to Cite
Blanco, F. J., Santibanez, J. F., Guerrero-Esteo, M., Langa, C., Vary, C. P.H. and Bernabeu, C. (2005), Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-β receptor complex. J. Cell. Physiol., 204: 574–584. doi: 10.1002/jcp.20311
- Issue published online: 26 MAY 2005
- Article first published online: 8 FEB 2005
- Manuscript Accepted: 30 NOV 2004
- Manuscript Received: 29 OCT 2004
- Fondo de Investigacion Sanitaria. Grant Number: PI020200
- Ministerio de Educacion y Ciencia. Grant Number: SAF2004-01390
- National Institutes of Health (National Center for Research Resources). Grant Number: P20 15555
- Ministerio de Educacion Cultura y Deporte
Transforming growth factor-β (TGF-β) signaling in endothelial cells is able to modulate angiogenesis and vascular remodeling, although the underlying molecular mechanisms remain poorly understood. Endoglin and ALK-1 are components of the TGF-β receptor complex, predominantly expressed in endothelial cells, and mutations in either endoglin or ALK-1 genes are responsible for the vascular dysplasia known as hereditary hemorrhagic telangiectasia. Here we find that the extracellular and cytoplasmic domains of the auxiliary TGF-β receptor endoglin interact with ALK-1 (a type I TGF-β receptor). In addition, endoglin potentiates TGF-β/ALK1 signaling, with the extracellular domain of endoglin contributing to this functional cooperation between endoglin and ALK-1. By contrast, endoglin appears to interfere with TGF-β/ALK-5 signaling. These results suggest that the functional association of endoglin with ALK-1 is critical for the endothelial responses to TGF-β. © 2005 Wiley-Liss, Inc.