Regulating fragile X gene transcription in the brain and beyond
Article first published online: 13 MAY 2005
Copyright © 2005 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 205, Issue 2, pages 170–175, November 2005
How to Cite
Lim, J. H., Booker, A. B. and Fallon, J. R. (2005), Regulating fragile X gene transcription in the brain and beyond. J. Cell. Physiol., 205: 170–175. doi: 10.1002/jcp.20401
- Issue published online: 29 AUG 2005
- Article first published online: 13 MAY 2005
- Manuscript Accepted: 23 FEB 2005
- Manuscript Received: 21 FEB 2005
- NIMH Predoctoral NRSA fellowship. Grant Number: MH065094
- National Institutes of Health. Grant Numbers: NS39321, RR15578
The past several years have seen remarkable growth in our understanding of the molecular processes underlying fragile X syndrome (FXS). Many studies have provided new insights into the regulation of Fmr1 gene expression and the potential function of its protein product. It is now known that the promoter elements modulating Fmr1 transcription involve a complex array of both cis and trans factors. Moreover, recent studies of epigenetic modification of chromatin have provided novel clues to unlocking the mysteries behind the regulation of Fmr1 expression. Here, we review the latest findings on the regulation of Fmr1 transcription. © 2005 Wiley-Liss, Inc.