Intracellular water homeostasis and the mammalian cellular osmotic stress response
Article first published online: 17 JUN 2005
Copyright © 2005 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 206, Issue 1, pages 9–15, January 2006
How to Cite
Ho, S. N. (2006), Intracellular water homeostasis and the mammalian cellular osmotic stress response. J. Cell. Physiol., 206: 9–15. doi: 10.1002/jcp.20445
- Issue published online: 28 OCT 2005
- Article first published online: 17 JUN 2005
- Manuscript Accepted: 11 APR 2005
- Manuscript Received: 15 MAR 2005
The cellular response to osmotic stress ensures that the concentration of water inside the cell is maintained within a range that is compatible with biologic function. Single cell organisms are particularly dependent on mechanisms that permit adaptation to osmotic stress because each individual cell is directly exposed to the external environment. Mammals, however, limit osmotic stress by establishing an internal aqueous environment in which intravascular water and electrolytes are subject to sensitive and dynamic, organism-based homeostatic regulation. Recent studies of NFAT5/TonEBP, an essential mammalian osmoregulatory transcription factor, demonstrate the unexpected yet critical significance of cell-based osmotic regulation in vivo. These results highlight the fundamental importance of maintaining intracellular water homeostasis in the face of varying cellular metabolic activity and distinct tissue microenvironments. © 2005 Wiley-Liss, Inc.