Leptin and cancer
Version of Record online: 18 AUG 2005
Copyright © 2005 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 207, Issue 1, pages 12–22, April 2006
How to Cite
Garofalo, C. and Surmacz, E. (2006), Leptin and cancer. J. Cell. Physiol., 207: 12–22. doi: 10.1002/jcp.20472
- Issue online: 24 JAN 2006
- Version of Record online: 18 AUG 2005
- Manuscript Accepted: 20 JUN 2005
- Manuscript Received: 3 MAY 2005
- Sbarro Health Research Organization
The prevalence of obesity has markedly increased over the past two decades, especially in the industrialized countries. While the impact of excess body weight on the development of cardiac disease and diabetes has been well documented, the link between obesity and carcinogenesis is just being recognized. This review will focus on the link between leptin, a cytokine that is elevated in obese individuals, and cancer development. First, we briefly discuss the biological functions of leptin and its signaling pathways. Then, we summarize the effects of leptin on different cancer types in experimental cellular and animal models. Next, we analyze epidemiological data on the relationship between obesity and the presence of cancer or cancer risk in patients. Finally, leptin as a target for cancer treatment and prevention will be discussed. J. Cell. Physiol. 207: 12–22, 2006. © 2005 Wiley-Liss, Inc.