Survivin study: An update of “What is the next wave?”
Article first published online: 23 MAR 2006
Copyright © 2006 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 208, Issue 3, pages 476–486, September 2006
How to Cite
Li, F. and Ling, X. (2006), Survivin study: An update of “What is the next wave?”. J. Cell. Physiol., 208: 476–486. doi: 10.1002/jcp.20634
- Issue published online: 26 JUN 2006
- Article first published online: 23 MAR 2006
- Manuscript Accepted: 31 JAN 2006
- Manuscript Received: 13 JAN 2006
- NIH R01. Grant Number: CA109481
- Concern Foundation
- NIH Cancer Center Support Grant. Grant Number: CA16056
Studies on survivin over the past 2–3 years have shown that survivin possesses multiple subcellular localizations and is a multi-functional molecule involved in many aspects of cellular processes and/or behaviors. The subcellular localization and function of the survivin splice variants, however, have not yet been well elucidated. We have, therefore, provided additional observations on several survivin splice variants for further exploration. This review article will update the role of survivin, and its splice variants in the mitosis/cell cycle, apoptosis, tumorigenesis, chemoprevention, drug/radiation resistance, and cancer therapeutics. J. Cell. Physiol. 208: 476–486, 2006. © 2006 Wiley-Liss, Inc.