MicroRNA: A new player in stem cells
Article first published online: 21 JUN 2006
Copyright © 2006 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 209, Issue 2, pages 266–269, November 2006
How to Cite
Zhang, B., Pan, X. and Anderson, T. A. (2006), MicroRNA: A new player in stem cells. J. Cell. Physiol., 209: 266–269. doi: 10.1002/jcp.20713
- Issue published online: 29 AUG 2006
- Article first published online: 21 JUN 2006
- Manuscript Accepted: 19 MAY 2006
- Manuscript Received: 18 MAY 2006
microRNAs (miRNAs) are an abundant class of endogenous non-protein-coding small RNAs, which negatively regulate gene expression at the posttranscriptional level in many developmental and metabolic processes. miRNAs regulate a variety of biological processes, including developmental timing, signal transduction, tissue differentiation and maintenance, disease, and carcinogenesis. Emerging evidence demonstrates that miRNAs also play an essential role in stem cell self-renewal and differentiation. Some miRNAs are specifically expressed in stem cells, control stem cell self-renewal, and differentiation through negatively regulating the expression of certain key genes in stem cells. J. Cell. Physiol. 209: 266–269, 2006. © 2006 Wiley-Liss, Inc.