F-actin-based Ca signaling—a critical comparison with the current concept of Ca signaling
Version of Record online: 5 JUL 2006
Copyright © 2006 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 209, Issue 2, pages 270–287, November 2006
How to Cite
Lange, K. and Gartzke, J. (2006), F-actin-based Ca signaling—a critical comparison with the current concept of Ca signaling. J. Cell. Physiol., 209: 270–287. doi: 10.1002/jcp.20717
- Issue online: 29 AUG 2006
- Version of Record online: 5 JUL 2006
- Manuscript Accepted: 5 JUN 2006
- Manuscript Received: 9 MAY 2006
A short comparative survey on the current idea of Ca signaling and the alternative concept of F-actin-based Ca signaling is given. The two hypotheses differ in one central aspect, the mechanism of Ca storage. The current theory rests on the assumption of Ca-accumulating endoplasmic/sarcoplasmic reticulum-derived vesicles equipped with an ATP-dependent Ca pump and IP3- or ryanodine-sensitive channel-receptors for Ca-release. The alternative hypothesis proceeds from the idea of Ca storage at the high-affinity binding sites of actin filaments. Cellular sites of F-actin-based Ca storage are microvilli and the submembrane cytoskeleton. Several specific features of Ca signaling such as store-channel coupling, quantal Ca release, spiking and oscillations, biphasic and “phasic” uptake kinetics, and Ca-induced Ca release (CICR), which are not adequately described by the current concept, are inherent properties of the F-actin system and its dynamic state of treadmilling. J. Cell. Physiol. 209: 270–287, 2006. © 2006 Wiley-Liss, Inc.