Functional characterization of PKDREJ, a male germ cell-restricted polycystin
Article first published online: 1 AUG 2006
Copyright © 2006 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 209, Issue 2, pages 493–500, November 2006
How to Cite
Sutton, K. A., Jungnickel, M. K., Ward, C. J., Harris, P. C. and Florman, H. M. (2006), Functional characterization of PKDREJ, a male germ cell-restricted polycystin. J. Cell. Physiol., 209: 493–500. doi: 10.1002/jcp.20755
- Issue published online: 29 AUG 2006
- Article first published online: 1 AUG 2006
- Manuscript Accepted: 14 JUN 2006
- Manuscript Received: 6 FEB 2006
- NICHD (NIH). Grant Numbers: HD029125, HD046948 (to HMF)
Polycystin-1 regulates a number of cellular processes through the formation of complexes with the polycystin-2 ion channel or with other signal transduction proteins. Polycystin-1 is expressed in many tissues but other members of this gene family are distributed in a more restricted fashion. PKDREJ expression has been detected only in the mammalian testis, where it is restricted to the spermatogenic lineage and retained in mature sperm. However, the functional characteristics of this protein and its role in sperm biology are not well understood. In this study it is shown that PKDREJ can modulate G protein signaling and associates with several members of the polycystin-2 family. These interactions, as well as polycystin-2 association with TRPC channels, are consistent with a role of this protein in the regulation of the acrosome reaction and in other aspects of sperm physiology. J. Cell. Physiol. 209: 493–500, 2006. © 2006 Wiley-Liss, Inc.