Deciphering the underlying genetic and epigenetic events leading to gastric carcinogenesis
Article first published online: 19 JAN 2007
Copyright © 2007 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 211, Issue 2, pages 287–295, May 2007
How to Cite
Vogiatzi, P., Vindigni, C., Roviello, F., Renieri, A. and Giordano, A. (2007), Deciphering the underlying genetic and epigenetic events leading to gastric carcinogenesis. J. Cell. Physiol., 211: 287–295. doi: 10.1002/jcp.20982
- Issue published online: 26 FEB 2007
- Article first published online: 19 JAN 2007
- Manuscript Accepted: 7 NOV 2006
- Manuscript Received: 4 NOV 2006
- Sbarro Health Research Organization
- NIH grants
Gastric cancer is a common aggressive malignancy. Although its incidence shows considerable variation among different countries, gastric cancer is still a major health problem worldwide. The causes of stomach cancer are not completely understood. What is clear is that gastric cancer is a multi-stage process involving genetic and epigenetic factors. This review is an in-depth study of the known genetic and epigenetic processes in the development of this tumor, and delineates possible approaches in gene and epigenetic therapy. J. Cell. Physiol. 211: 287–295, 2007. © 2007 Wiley-Liss, Inc.