Deciphering the underlying genetic and epigenetic events leading to gastric carcinogenesis

Authors

  • Paraskevi Vogiatzi,

    1. Department of Molecular Biology, Medical Genetics, University of Siena, Siena, Italy
    2. Department of Human Pathology and Oncology, University of Siena, Siena, Italy
    3. Sbarro Institute for Cancer Research and Molecular Medicine, Centre for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania
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  • Carla Vindigni,

    1. Department of Human Pathology and Oncology, University of Siena, Siena, Italy
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  • Franco Roviello,

    1. Department of Human Pathology and Oncology, University of Siena, Siena, Italy
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  • Alessandra Renieri,

    1. Department of Molecular Biology, Medical Genetics, University of Siena, Siena, Italy
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  • Antonio Giordano

    Corresponding author
    1. Department of Human Pathology and Oncology, University of Siena, Siena, Italy
    2. Sbarro Institute for Cancer Research and Molecular Medicine, Centre for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania
    • Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Bio Life Sciences Building Suite 333, 1900 N. 12th Street, Philadelphia, PA 19122.
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Abstract

Gastric cancer is a common aggressive malignancy. Although its incidence shows considerable variation among different countries, gastric cancer is still a major health problem worldwide. The causes of stomach cancer are not completely understood. What is clear is that gastric cancer is a multi-stage process involving genetic and epigenetic factors. This review is an in-depth study of the known genetic and epigenetic processes in the development of this tumor, and delineates possible approaches in gene and epigenetic therapy. J. Cell. Physiol. 211: 287–295, 2007. © 2007 Wiley-Liss, Inc.

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