DNA methylation: The nuts and bolts of repression
Article first published online: 20 AUG 2007
Copyright © 2007 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 213, Issue 2, pages 384–390, November 2007
How to Cite
Miranda, T. B. and Jones, P. A. (2007), DNA methylation: The nuts and bolts of repression. J. Cell. Physiol., 213: 384–390. doi: 10.1002/jcp.21224
- Issue published online: 27 AUG 2007
- Article first published online: 20 AUG 2007
- Manuscript Accepted: 15 JUN 2007
- Manuscript Received: 13 JUN 2007
- NIH. Grant Number: R01 CA82422
- TBM is supported by the American Cancer Society Postdoctoral Fellowship. Grant Number: PF-07-100-01-GMC
DNA methylation is an epigenetic modification which plays an important role in chromatin organization and gene expression. DNA methylation can silence genes and repetitive elements through a process which leads to the alteration of chromatin structure. The mechanisms which target DNA methylation to specific sites in the genome are not fully understood. In this review, we will discuss the mechanisms which lead to the long-term silencing of genes and will survey the progression that has been made in determining the targeted mechanisms for de novo DNA methylation. J. Cell. Physiol. 213: 384–390, 2007. © 2007 Wiley-Liss, Inc.