SEARCH

SEARCH BY CITATION

Literature Cited

  • Aigner T, Bartnik E, Sohler F, Zimmer R. 2004. Functional genomics of osteoarthritis: On the way to evaluate disease hypotheses. Clin Orthop Relat Res 427: S138S143.
  • Aigner T, Fundel K, Saas J, Gebhard PM, Haag J, Weiss T, Zien A, Obermayr F, Zimmer R, Bartnik E. 2006. Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis. Arthritis Rheum 54: 35333544.
  • Aigner T, Haag J, Martin J, Buckwalter J. 2007. Osteoarthritis: Aging of matrix and cells—going for a remedy. Curr Drug Targets 8: 325331.
  • Ameye LG, Young MF. 2006. Animal models of osteoarthritis: Lessons learned while seeking the “Holy Grail”. Curr Opin Rheumatol 18: 537547.
  • Barksby HE, Hui W, Wappler I, Peters HH, Milner JM, Richards CD, Cawston TE, Rowan AD. 2006. Interleukin-1 in combination with oncostatin M up-regulates multiple genes in chondrocytes: Implications for cartilage destruction and repair. Arthritis Rheum 54: 540550.
  • Barry FP, Murphy JM. 2004. Mesenchymal stem cells: Clinical applications and biological characterization. Int J Biochem Cell Biol 36: 568584.
  • Bau B, Gebhard PM, Haag J, Knorr T, Bartnik E, Aigner T. 2002. Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro. Arthritis Rheum 46: 26482657.
  • Bendele AM. 2001. Animal models of osteoarthritis. J Musculoskelet Neuronal Interact 1: 363376.
  • Benito MJ, Veale DJ, FitzGerald O, van den Berg WB, Bresnihan B. 2005. Synovial tissue inflammation in early and late osteoarthritis. Ann Rheum Dis 64: 12631267.
  • Blaney Davidson EN, van der Kraan PM, van den Berg WB. 2007. TGF-beta and osteoarthritis. Osteoarthritis Cartilage 15: 597604.
  • Borzi RM, Mazzetti I, Marcu KB, Facchini A. 2004. Chemokines in cartilage degradation. Clin Orthop Relat Res 427: S53S61.
  • Brandt KD, Radin EL, Dieppe PA, van de Putte L. 2006. Yet more evidence that osteoarthritis is not a cartilage disease. Ann Rheum Dis 65: 12611264.
  • Buckland-Wright C. 2004. Subchondral bone changes in hand and knee osteoarthritis detected by radiography. Osteoarthritis Cartilage 12: S10S19.
  • Bukulmez H, Matthews AL, Sullivan CM, Chen C, Kraay MJ, Elston RC, Moskowitz RW, Goldberg VM, Warman ML. 2006. Hip joint replacement surgery for idiopathic osteoarthritis aggregates in families. Arthritis Res Ther 8: R25.
  • Bullough PG. 2004. The role of joint architecture in the etiology of arthritis. Osteoarthritis Cartilage 12: S2S9.
  • Burr DB. 2004. Anatomy and physiology of the mineralized tissues: Role in the pathogenesis of osteoarthrosis. Osteoarthritis Cartilage 12: S20S30.
  • Burr DB, Schaffler MB. 1997. The involvement of subchondral mineralized tissues in osteoarthrosis: quantitative microscopic evidence. Microsc Res Tech 37: 343357.
  • Burstein D, Gray ML. 2006. Is MRI fulfilling its promise for molecular imaging of cartilage in arthritis? Osteoarthritis Cartilage 14: 10871090.
  • Cahue S, Sharma L, Dunlop D, Ionescu M, Song J, Lobanok T, King L, Poole AR. 2007. The ratio of type II collagen breakdown to synthesis and its relationship with the progression of knee osteoarthritis. Osteoarthritis Cartilage 15: 819823.
  • Caplan AI. 2005. Review: Mesenchymal stem cells: Cell-based reconstructive therapy in orthopedics. Tissue Eng 11: 11981211.
  • Carrington JL. 2005. Aging bone and cartilage: Cross-cutting issues. Biochem Biophys Res Commun 328: 700708.
  • Cawston TE, Wilson AJ. 2006. Understanding the role of tissue degrading enzymes and their inhibitors in development and disease. Best Pract Res Clin Rheumatol 20: 9831002.
  • Charni-Ben Tabassi N, Garnero P. 2007. Monitoring cartilage turnover. Curr Rheumatol Rep 9: 1624.
  • Coats AM, Zioupos P, Aspden RM. 2003. Material properties of subchondral bone from patients with osteoporosis or osteoarthritis by microindentation testing and electron probe microanalysis. Calcif Tissue Int 73: 6671.
  • Ding C, Cicuttini F, Jones G. 2007. Tibial subchondral bone size and knee cartilage defects: Relevance to knee osteoarthritis. Osteoarthritis Cartilage 15: 479486.
  • Dudhia J. 2005. Aggrecan, aging and assembly in articular cartilage. Cell Mol Life Sci 62: 22412256.
  • Englund M, Lohmander LS. 2004. Risk factors for symptomatic knee osteoarthritis fifteen to twenty-two years after meniscectomy. Arthritis Rheum 50: 28112819.
  • Evans CH. 2005. Novel biological approaches to the intra-articular treatment of osteoarthritis. BioDrugs 19: 355362.
  • Felson DT. 2006. Clinical practice. Osteoarthritis of the knee. N Engl J Med 354: 841848.
  • Felson DT, Chaisson CE, Hill CL, Totterman SM, Gale ME, Skinner KM, Kazis L, Gale DR. 2001. The association of bone marrow lesions with pain in knee osteoarthritis. Ann Intern Med 134: 541549.
  • Fitzgerald JB, Jin M, Dean D, Wood DJ, Zheng MH, Grodzinsky AJ. 2004. Mechanical compression of cartilage explants induces multiple time-dependent gene expression patterns and involves intracellular calcium and cyclic AMP. J Biol Chem 279: 1950219511.
  • Fukui N, Zhu Y, Maloney WJ, Clohisy J, Sandell LJ. 2003. Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-α in normal and osteoarthritic chondrocytes. J Bone Joint Surg Am 85: 5966.
  • Glasson SS. 2007. In vivo osteoarthritis target validation utilizing genetically-modified mice. Curr Drug Targets 8: 367376.
  • Goldring MB. 2006. Are bone morphogenetic proteins effective inducers of cartilage repair? Ex vivo transduction of muscle-derived stem cells. Arthritis Rheum 54: 387389.
  • Goldring MB. 2007. Update on the chondrocyte lineage and implications for cell therapy in osteoarthritis. In: SharmaL, BerenbaumF, editors. Osteoarthritis: A companion to rheumatology 1st edition. Philadelphia: Mosby, Inc., an affiliate of Elsevier, Inc. pp 5376.
  • Goldring MB, Berenbaum F. 2004. The regulation of chondrocyte function by proinflammatory mediators: Prostaglandins and nitric oxide. Clin Orthop 427: S37S46.
  • Goldring SR, Goldring MB. 2004. The role of cytokines in cartilage matrix degeneration in osteoarthritis. Clin Orthop 423: S27S36.
  • Goldring MB, Tsuchimochi K, Ijiri K. 2006. The control of chondrogenesis. J Cell Biochem 97: 3344.
  • Guilak F, Fermor B, Keefe FJ, Kraus VB, Olson SA, Pisetsky DS, Setton LA, Weinberg JB. 2004. The role of biomechanics and inflammation in cartilage injury and repair. Clin Orthop Relat Res 427: 1726.
  • Helminen HJ, Saamanen AM, Salminen H, Hyttinen MM. 2002. Transgenic mouse models for studying the role of cartilage macromolecules in osteoarthritis. Rheumatol (Oxf) 41: 848856.
  • Hermansson M, Sawaji Y, Bolton M, Alexander S, Wallace A, Begum S, Wait R, Saklatvala J. 2004. Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin betaA (activin A), a regulatory molecule for chondrocytes. J Biol Chem 279: 4351443521.
  • Hill CL, Gale DG, Chaisson CE, Skinner K, Kazis L, Gale ME, Felson DT. 2001. Knee effusions, popliteal cysts, and synovial thickening: association with knee pain in osteoarthritis. J Rheumatol 28: 13301337.
  • Horton WE Jr, Yagi R, Laverty D, Weiner S. 2005. Overview of studies comparing human normal cartilage with minimal and advanced osteoarthritic cartilage. Clin Exp Rheumatol 23: 103112.
  • Huang JI, Kazmi N, Durbhakula MM, Hering TM, Yoo JU, Johnstone B. 2005. Chondrogenic potential of progenitor cells derived from human bone marrow and adipose tissue: A patient-matched comparison. J Orthop Res 23: 13831389.
  • Hunziker EB. 2002. Articular cartilage repair: Basic science and clinical progress. A review of the current status and prospects. Osteoarthritis Cartilage 10: 432463.
  • Ijiri K, Zerbini LF, Peng H, Correa RG, Lu B, Walsh N, Zhao Y, Taniguchi N, Huang XL, Otu H, Wang H, Wang JF, Komiya S, Ducy P, Rahman MU, Flavell RA, Gravallese EM, Oettgen P, Libermann TA, Goldring MB. 2005. A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation. J Biol Chem 280: 3854438555.
  • Ijiri K, Zerbini LF, Peng H, Otu H, Tsuchimochi K, Otero M, Walsh N, Bierbaum BE, Mattingly D, van Flandern G, Komiya S, Aigner T, Libermann TA, Goldring MB. 2007. A role for GADD45β as a survival factor in articular chondrocytes in normal and osteoarthritic cartilage. Arthritis Rheum in revision.
  • Ikeda T, Kamekura S, Mabuchi A, Kou I, Seki S, Takato T, Nakamura K, Kawaguchi H, Ikegawa S, Chung UI. 2004. The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage. Arthritis Rheum 50: 35613573.
  • Kamekura S, Hoshi K, Shimoaka T, Chung U, Chikuda H, Yamada T, Uchida M, Ogata N, Seichi A, Nakamura K, Kawaguchi H. 2005. Osteoarthritis development in novel experimental mouse models induced by knee joint instability. Osteoarthritis Cartilage 13: 632641.
  • Kamekura S, Kawasaki Y, Hoshi K, Shimoaka T, Chikuda H, Maruyama Z, Komori T, Sato S, Takeda S, Karsenty G, Nakamura K, Chung UI, Kawaguchi H. 2006. Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability. Arthritis Rheum 54: 24622470.
  • Kishimoto K, Kitazawa R, Kurosaka M, Maeda S, Kitazawa S. 2005. Expression profile of genes related to osteoclastogenesis in mouse growth plate and articular cartilage. Histochem Cell Biol 25: 593602.
  • Kizawa H, Kou I, Iida A, Sudo A, Miyamoto Y, Fukuda A, Mabuchi A, Kotani A, Kawakami A, Yamamoto S, Uchida A, Nakamura K, Notoya K, Nakamura Y, Ikegawa S. 2005. An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis. Nat Genet 37: 138144.
  • Komuro H, Olee T, Kuhn K, Quach J, Brinson DC, Shikhman A, Valbracht J, Creighton-Achermann L, Lotz M. 2001. The osteoprotegerin/receptor activator of nuclear factor kappaB/receptor activator of nuclear factor kappaB ligand system in cartilage. Arthritis Rheum 44: 27682776.
  • Kuo CK, Li WJ, Mauck RL, Tuan RS. 2006. Cartilage tissue engineering: Its potential and uses. Curr Opin Rheumatol 18: 6473.
  • Kuroda R, Usas A, Kubo S, Corsi K, Peng H, Rose T, Cummins J, Fu FH, Huard J. 2006. Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells. Arthritis Rheum 54: 433442.
  • Kurz B, Lemke AK, Fay J, Pufe T, Grodzinsky AJ, Schunke M. 2005. Pathomechanisms of cartilage destruction by mechanical injury. Ann Anat 187: 473485.
  • Lane LB, Villacin A, Bullough PG. 1977. The vascularity and remodelling of subchondrial bone and calcified cartilage in adult human femoral and humeral heads. An age- and stress-related phenomenon. J Bone Joint Surg Br 59: 272278.
  • Lane NE, Lian K, Nevitt MC, Zmuda JM, Lui L, Li J, Wang J, Fontecha M, Umblas N, Rosenbach M, de Leon P, Corr M. 2006. Frizzled-related protein variants are risk factors for hip osteoarthritis. Arthritis Rheum 54: 12461254.
  • Li Y, Xu L, Olsen BR. 2007. Lessons from genetic forms of osteoarthritis for the pathogenesis of the disease. Osteoarthritis Cartilage Jun 13; [Epub ahead of print].
  • Loeser RF. 2006. Molecular mechanisms of cartilage destruction: Mechanics, inflammatory mediators, and aging collide. Arthritis Rheum 54: 13571360.
  • Lories RJ, Luyten FP. 2005. Bone Morphogenetic Protein signaling in joint homeostasis and disease. Cytokine Growth Factor Rev 16: 287298.
  • Loughlin J. 2005. Polymorphism in signal transduction is a major route through which osteoarthritis susceptibility is acting. Curr Opin Rheumatol 17: 629633.
  • Loughlin J, Dowling B, Chapman K, Marcelline L, Mustafa Z, Southam L, Ferreira A, Ciesielski C, Carson DA, Corr M. 2004. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proc Natl Acad Sci USA 101: 97579762.
  • Lubberts E, Koenders MI, van den Berg WB. 2005. The role of T cell interleukin-17 in conducting destructive arthritis: Lessons from animal models. Arthritis Res Ther 7: 2937.
  • Magne D, Vinatier C, Julien M, Weiss P, Guicheux J. 2005. Mesenchymal stem cell therapy to rebuild cartilage. Trends Mol Med 11: 519526.
  • Majumdar S, Li X, Blumenkrantz G, Saldanha K, Ma CB, Kim H, Lozano J, Link T. 2006. MR imaging and early cartilage degeneration and strategies for monitoring regeneration. J Musculoskelet Neuronal Interact 6: 382384.
  • Maroudas A, Bayliss MT, Uchitel-Kaushansky N, Schneiderman R, Gilav E. 1998. Aggrecan turnover in human articular cartilage: Use of aspartic acid racemization as a marker of molecular age. Arch Biochem Biophys 350: 6171.
  • Martin JA, Brown TD, Heiner AD, Buckwalter JA. 2004. Chondrocyte senescence, joint loading and osteoarthritis. Clin Orthop Relat Res 427: S96S103.
  • McDougall JJ. 2006a. Arthritis and pain. Neurogenic origin of joint pain. Arthritis Res Ther 8: 220.
  • McDougall JJ. 2006b. Pain and OA. J Musculoskelet Neuronal Interact 6: 385386.
  • Messent EA, Ward RJ, Tonkin CJ, Buckland-Wright C. 2006. Differences in trabecular structure between knees with and without osteoarthritis quantified by macro and standard radiography, respectively. Osteoarthritis Cartilage 14: 13021305.
  • Millward-Sadler SJ, Salter DM. 2004. Integrin-dependent signal cascades in chondrocyte mechanotransduction. Ann Biomed Eng 32: 435446.
  • Nakase T, Miyaji T, Tomita T, Kaneko M, Kuriyama K, Myoui A, Sugamoto K, Ochi T, Yoshikawa H. 2003. Localization of bone morphogenetic protein-2 in human osteoarthritic cartilage and osteophyte. Osteoarthritis Cartilage 11: 278284.
  • Neuhold LA, Killar L, Zhao W, Sung ML, Warner L, Kulik J, Turner J, Wu W, Billinghurst C, Meijers T, Poole AR, Babij P, DeGennaro LJ. 2001. Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice. J Clin Invest 107(1): 3544.
  • Niissalo S, Hukkanen M, Imai S, Tornwall J, Konttinen YT. 2002. Neuropeptides in experimental and degenerative arthritis. Ann NY Acad Sci 966: 384399.
  • Palmer GD, Steinert A, Pascher A, Gouze E, Gouze JN, Betz O, Johnstone B, Evans CH, Ghivizzani SC. 2005. Gene-induced chondrogenesis of primary mesenchymal stem cells in vitro. Mol Ther 12: 219228.
  • Pettit AR, Ji H, von Stechow D, Muller R, Goldring SR, Choi Y, Benoist C, Gravallese EM. 2001. TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis. Am J Pathol 159: 16891699.
  • Plaas A, Osborn B, Yoshihara Y, Bai Y, Bloom T, Nelson F, Mikecz K, Sandy JD. 2007. Aggrecanolysis in human osteoarthritis: Confocal localization and biochemical characterization of ADAMTS5-hyaluronan complexes in articular cartilages. Osteoarthritis Cartilage 15: 719734.
  • Poole AR, Guilak F, Abramson SB. 2007. Etiopathogenesis of osteoarthritis. In: MoskowitzRW, AltmanRW, HochbergMC, BuckwalterJA, GoldbergVM, editors. Osteoarthritis: Diagnosis and medical/surgical management. 4th edition. Philadelphia: Lippincott, Williams, and Wilkins. pp 2749.
  • Pritzker KP, Gay S, Jimenez SA, Ostergaard K, Pelletier JP, Revell PA, Salter D, van den Berg WB. 2006. Osteoarthritis cartilage histopathology: Grading and staging. Osteoarthritis Cartilage 14: 1329.
  • Pulai JI, Chen H, Im HJ, Kumar S, Hanning C, Hegde PS, Loeser RF. 2005. NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments. J Immunol 174: 57815788.
  • Radin EL, Rose RM. 1986. Role of subchondral bone in the initiation and progression of cartilage damage. Clin Orthop Relat Res 213: 3440.
  • Roos EM. 2005. Joint injury causes knee osteoarthritis in young adults. Curr Opin Rheumatol 17: 195200.
  • Rousseau JC, Delmas PD. 2007. Biological markers in osteoarthritis. Nat Clin Pract Rheumatol 3: 346356.
  • Saamanen AM, Vuorio E. 2004. Generation and use of transgenic mice as models of osteoarthritis. Methods Mol Med 101: 123.
  • Sahebjam S, Khokha R, Mort JS. 2007. Increased collagen and aggrecan degradation with age in the joints of Timp3(−/−) mice. Arthritis Rheum 56: 905909.
  • Sandell LJ, Aigner T. 2001. Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis. Arthritis Res 3: 107113.
  • Schaible HG, Ebersberger A, Von Banchet GS. 2002. Mechanisms of pain in arthritis. Ann NY Acad Sci 966: 343354.
  • Schuelert N, McDougall JJ. 2006. Electrophysiological evidence that the vasoactive intestinal peptide receptor antagonist VIP 6-28reduces nociception in an animal model of osteoarthritis. Osteoarthritis Cartilage 14: 11551162.
  • Smith MM, Little CB. 2007. Experimental models of osteoarthritis. In: MoskowitzRW, AltmanRW, HochbergMC, BuckwalterJA, GoldbergVM, editors. Osteoarthritis: Diagnosis and medical/surgical management. 4th edition. Philadelphia: Lippincott, Williams, and Wilkins. pp 107125.
  • Tamamura Y, Otani T, Kanatani N, Koyama E, Kitagaki J, Komori T, Yamada Y, Costantini F, Wakisaka S, Pacifici M, Iwamoto M, Enomoto-Iwamoto M. 2005. Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification. J Biol Chem 280: 1918519195.
  • Tchetina EV, Squires G, Poole AR. 2005. Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions. J Rheumatol 32: 876886.
  • Tchetina EV, Antoniou J, Tanzer M, Zukor DJ, Poole AR. 2006. Transforming growth factor-beta2 suppresses collagen cleavage in cultured human osteoarthritic cartilage, reduces expression of genes associated with chondrocyte hypertrophy and degradation, and increases prostaglandin E(2) production. Am J Pathol 168: 131140.
  • Tetlow LC, Adlam DJ, Woolley DE. 2001. Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage. Arthritis Rheum 44: 585594.
  • Tew SR, Li Y, Pothacharoen P, Tweats LM, Hawkins RE, Hardingham TE. 2005. Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes. Osteoarthritis Cartilage 13: 8089.
  • Valdes AM, Van Oene M, Hart DJ, Surdulescu GL, Loughlin J, Doherty M, Spector TD. 2006. Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. Arthritis Rheum 54: 533539.
  • Valdes AM, Loughlin J, Oene MV, Chapman K, Surdulescu GL, Doherty M, Spector TD. 2007. Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee. Arthritis Rheum 56: 137146.
  • Verzijl N, DeGroot J, Thorpe SR, Bank RA, Shaw JN, Lyons TJ, Bijlsma JW, Lafeber FP, Baynes JW, TeKoppele JM. 2000. Effect of collagen turnover on the accumulation of advanced glycation end products. J Biol Chem 275: 3902739031.
  • Verzijl N, Bank RA, TeKoppele JM, DeGroot J. 2003. AGEing and osteoarthritis: A different perspective. Curr Opin Rheumatol 15: 616622.
  • Walsh DA, Bonnet CS, Turner EL, Wilson D, Situ M, McWilliams DF. 2007. Angiogenesis in the synovium and at the osteochondral junction in osteoarthritis. Osteoarthritis Cartilage 15: 743751.
  • Wang X, Manner PA, Horner A, Shum L, Tuan RS, Nuckolls GH. 2004. Regulation of MMP-13 expression by RUNX2 and FGF2 in osteoarthritic cartilage. Osteoarthritis Cartilage 12: 963973.
  • Wu W, Billinghurst RC, Pidoux I, Antoniou J, Zukor D, Tanzer M, Poole AR. 2002. Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13. Arthritis Rheum 46: 20872094.
  • Xu L, Peng H, Glasson S, Lee PL, Hu K, Ijiri K, Olsen BR, Goldring MB, Li Y. 2007. Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis. Arthritis Rheum 56: 26632673.
  • Yang L, Carlson SG, McBurney D, Horton WE, Jr. 2005. Multiple signals induce endoplasmic reticulum stress in both primary and immortalized chondrocytes resulting in loss of differentiation, impaired cell growth, and apoptosis. J Biol Chem 280: 3115631165.
  • Young MF. 2005. Mouse models of osteoarthritis provide new research tools. Trends Pharmacol Sci 26: 333335.