Stem cells: The root of prostate cancer?
Article first published online: 5 MAY 2008
Copyright © 2008 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 216, Issue 2, pages 332–336, August 2008
How to Cite
Kasper, S. (2008), Stem cells: The root of prostate cancer?. J. Cell. Physiol., 216: 332–336. doi: 10.1002/jcp.21489
- Issue published online: 23 MAY 2008
- Article first published online: 5 MAY 2008
- Manuscript Accepted: 2 APR 2008
- Manuscript Received: 31 MAR 2008
- National Institute of Diabetes & Digestive & Kidney Diseases. Grant Number: R01DK60957
- The Frances Williams Preston Laboratories of the T.J. Martell Foundation
The cancer stem cell (CSC) model states that tumors contain a reservoir of self-renewing cells that maintain the heterogeneous cell population of the tumor. These cells appear to be resistant to therapy and can therefore survive to repopulate the tumor during progression to therapy resistant disease. The biology of CSCs is still not definitive since it is difficult to isolate them from solid tumors and analyze their characteristics in vitro. Another challenge is to correlate these characteristics with tumor development and progression in vivo. Using the prostate CSC as a model, this review presents the CSC hypothesis, reviews the origin, identification and functions of prostate CSCs, and discusses the clinical implications and therapeutic challenges CSCs have for cancer therapy. J. Cell. Physiol. 216: 332–336, 2008. © 2008 Wiley-Liss, Inc.