What do we know about serotonin?
Article first published online: 23 JUL 2008
Copyright © 2008 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 217, Issue 2, pages 301–306, November 2008
How to Cite
Jonnakuty, C. and Gragnoli, C. (2008), What do we know about serotonin?. J. Cell. Physiol., 217: 301–306. doi: 10.1002/jcp.21533
- Issue published online: 22 AUG 2008
- Article first published online: 23 JUL 2008
- Manuscript Accepted: 6 JUN 2008
- Manuscript Received: 26 FEB 2008
- Dean's Pilot and Feasibility Grant. Grant Number: D1BTH06321-01
- Office for the Advancement of Telehealth (OAT)
- Health Resources and Services Administration
- Pennsylvania Department of Health using Tobacco Settlement Funds
The present review focuses on what is known of basic serotonin physiology in the human body. Here, we describe serotonin biochemistry and metabolism and summarize the results of studies that have contributed significantly to our understanding of serotonin physiology. We report the well-established role of serotonin in cardiovascular, gastrointestinal, and circulatory physiology. Emphasis is placed on the role of serotonin in peripheral physiological systems rather than in the central nervous system. A brief overview is provided on the emerging role of serotonin in novel areas such as bone pathways and glucose uptake. We also report a select few animal studies and animal models that have provided worthwhile contributions to the understanding of serotonin in human physiology. In addition, we summarize the results of large-scale genetic studies on serotonin and serotonin transporter genes, performed in relation to behavioral and mood disorders. J. Cell. Physiol. 217: 301–306, 2008. © 2008 Wiley-Liss, Inc.