Human embryonic stem cells and cardiac cell fate
Article first published online: 12 NOV 2008
Copyright © 2008 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 218, Issue 3, pages 455–459, March 2009
How to Cite
Nury, D., Neri, T. and Pucéat, M. (2009), Human embryonic stem cells and cardiac cell fate. J. Cell. Physiol., 218: 455–459. doi: 10.1002/jcp.21631
- Issue published online: 18 DEC 2008
- Article first published online: 12 NOV 2008
- Manuscript Accepted: 6 OCT 2008
- Manuscript Received: 2 SEP 2008
- National Research Agency (Programme Blanc)
- LeDucq Foundation (MITRAL Network, Paris)
Human embryonic stem (HES) cells are pluripotent and give rise to any cell lineage. More specifically, how the first embryonic lineage (i.e., cardiac lineage) is acquired remains in many aspects questionable. Herein, we summarize the protocols that have been used to direct the fate of HES cells toward the cardiomyocytic lineage. We further discuss the regulation of transcriptional pathways underlying this process of differentiation. Finally, we propose perspectives of this research in the near future. J. Cell. Physiol. 218: 455–459, 2009. © 2008 Wiley-Liss, Inc.