MicroRNAs: Novel Regulators During the Immune Response
Article first published online: 25 NOV 2008
Copyright © 2008 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 218, Issue 3, pages 467–472, March 2009
How to Cite
Bi, Y., Liu, G. and Yang, R. (2009), MicroRNAs: Novel Regulators During the Immune Response. J. Cell. Physiol., 218: 467–472. doi: 10.1002/jcp.21639
- Issue published online: 18 DEC 2008
- Article first published online: 25 NOV 2008
- Manuscript Accepted: 15 OCT 2008
- Manuscript Received: 12 OCT 2008
- National Natural Science Foundation of China. Grant Numbers: 30801042, 30430620, 30670103
- Distinguished Young Scholars. Grant Number: 30525025
MicroRNAs (miRNAs), an abundant class of highly conversed, small noncoding RNAs, present an entirely new way of post-transcriptional gene regulation. miRNAs play a key role in diverse biological processes, such as embryogenesis, differentiation, inflammation, viral infections, and carcinogenesis. Recently, more studies showed the importance of these noncoding small RNAs on immune system development and response, and miRNAs are found to involve in the regulation of immunity, including the development and differentiation of immnue cells, antibody production and the inflammatory mediator release. Here, the latest findings were summarized to explore the function and mechanism of miRNAs in modulating innate and adaptive immune responses. J. Cell. Physiol. 218: 467–472, 2009. © 2008 Wiley-Liss, Inc.