Original Article

Genome based cell population heterogeneity promotes tumorigenicity: The evolutionary mechanism of cancer

  1. Christine J. Ye1,
  2. Joshua B. Stevens1,
  3. Guo Liu1,
  4. Steven W. Bremer1,
  5. Aruna S. Jaiswal2,
  6. Karen J. Ye3,
  7. Ming-Fong Lin4,
  8. Lesley Lawrenson1,
  9. Wayne D. Lancaster1,
  10. Markku Kurkinen1,
  11. Joshua D. Liao1,
  12. C. Gary Gairola5,
  13. Malathy P.V. Shekhar6,
  14. Satya Narayan2,
  15. Fred R. Miller6,
  16. Henry H.Q. Heng1,6,*

Article first published online: 29 DEC 2008

DOI: 10.1002/jcp.21663

Issue

Journal of Cellular Physiology

Journal of Cellular Physiology

Volume 219, Issue 2, pages 288–300, May 2009

Additional Information

How to Cite

Ye, C. J., Stevens, J. B., Liu, G., Bremer, S. W., Jaiswal, A. S., Ye, K. J., Lin, M.-F., Lawrenson, L., Lancaster, W. D., Kurkinen, M., Liao, J. D., Gairola, C. G., Shekhar, M. P.V., Narayan, S., Miller, F. R. and Heng, H. H.Q. (2009), Genome based cell population heterogeneity promotes tumorigenicity: The evolutionary mechanism of cancer. J. Cell. Physiol., 219: 288–300. doi: 10.1002/jcp.21663

Author Information

  1. 1

    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan

  2. 2

    Department of Anatomy and Cell Biology, UF Shands Cancer Center, University of Florida, Gainesville, Florida

  3. 3

    SeeDNA Biotech, Windsor, Ontario, Canada

  4. 4

    Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, Nebraska

  5. 5

    Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky

  6. 6

    Karmanos Cancer Institute, Detroit, Michigan

*3226 Scott Hall, 540 E. Canfield, Detroit, MI 48201.

Publication History

  1. Issue published online: 23 FEB 2009
  2. Article first published online: 29 DEC 2008
  3. Manuscript Accepted: 10 NOV 2008
  4. Manuscript Received: 29 SEP 2008

Funded by

  • Susan G. Komen Breast Cancer Foundation
  • Office of the Vice President for Research to Henry H. Q Heng
  • NCI-NIH. Grant Number: R01-CA100247
  • Flight Attendant Medical Research Institute, Miami, FL

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