Mini-Review

Regulation of adult bone turnover by sex steroids

  1. Baruch Frenkel1,2,3,*,
  2. Albert Hong1,3,
  3. Sanjeev K. Baniwal1,3,
  4. Gerhard A. Coetzee4,5,6,
  5. Claes Ohlsson7,
  6. Omar Khalid1,3,
  7. Yankel Gabet1,3

Article first published online: 16 APR 2010

DOI: 10.1002/jcp.22159

Issue

Journal of Cellular Physiology

Journal of Cellular Physiology

Volume 224, Issue 2, pages 305–310, August 2010

Additional Information

How to Cite

Frenkel, B., Hong, A., Baniwal, S. K., Coetzee, G. A., Ohlsson, C., Khalid, O. and Gabet, Y. (2010), Regulation of adult bone turnover by sex steroids. J. Cell. Physiol., 224: 305–310. doi: 10.1002/jcp.22159

Author Information

  1. 1

    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California

  2. 2

    Department of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California

  3. 3

    Institute of Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California

  4. 4

    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California

  5. 5

    Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California

  6. 6

    Norris Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California

  7. 7

    Center for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

*Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, 2250 Alcazar Street, CSC 240, Los Angeles, CA 90033.

Publication History

  1. Issue published online: 22 MAY 2010
  2. Article first published online: 16 APR 2010
  3. Manuscript Accepted: 2 MAR 2010
  4. Manuscript Received: 26 FEB 2010

Funded by

  • National Institutes of Health. Grant Numbers: DK071122, AR047052, CA109147
  • Swedish Research Council
  • Swedish Foundation for Strategic Research
  • ALF/LUA in Gothenburg
  • Lundberg Foundation
  • Torsten and Ragnar Söderberg's Foundation
  • Novo Nordisk Foundation
  • European Commission. Grant Number: HEALTH-F2-2008-201865-GEFOS
  • Arthritis Foundation

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (110K)

Abstract

Recent reports reveal increasing complexity of mechanisms underlying the bone sparing effects of sex steroids. This review focuses on mechanisms by which sex steroids attenuate endocortical and trabecular adult bone turnover, perhaps their most important property as bone mass regulators. Clearly, estrogen withdrawal increases osteoclast number and bone resorption; however, important open questions are the extent to which osteoblasts and their precursors are involved, and the relative contributions of the RANK/RANKL/OPG system, Fas ligand and Runx2. In addition to reviewing these aspects of estrogen action, we also discuss proskeletal effects of androgens on the adult male skeleton, including aromatization to estrogens and male-specific mechanisms. Detailed understanding of skeletal site- and gender-dependent mechanisms by which sex steroids protect the adult skeleton will provide the foundation for improved risk assessment, prevention and management of osteoporosis. J. Cell. Physiol. 224: 305–310, 2010. © 2010 Wiley-Liss, Inc.

View Full Article (HTML) Get PDF (110K)