Cross-talk between the insulin-like growth factor (IGF) axis and membrane integrins to regulate cell physiology
Article first published online: 28 APR 2010
Copyright © 2010 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 224, Issue 3, pages 605–611, September 2010
How to Cite
Beattie, J., McIntosh, L. and van der Walle, C. F. (2010), Cross-talk between the insulin-like growth factor (IGF) axis and membrane integrins to regulate cell physiology. J. Cell. Physiol., 224: 605–611. doi: 10.1002/jcp.22183
- Issue published online: 25 JUN 2010
- Article first published online: 28 APR 2010
- Manuscript Accepted: 19 MAR 2010
- Manuscript Received: 18 MAR 2010
The biology of cross-talk between activated growth factor receptors and cell-surface integrins is an area which has attracted much interest in recent years (Schwartz and Ginsberg, 2002). This review discusses the relationship between the insulin-like growth factor (IGF) axis and cell-surface integrin receptors in the regulation of various aspects of cell physiology. Key to these interactions are signals transmitted between integrins and the IGF-I receptor (IGF-IR) when either or both are bound to their cognate ligands and we will review the current state of knowledge in this area. The IGF axis comprises many molecular components and we will also discuss the potential role of these species in cross-talk with the integrin receptor. With respect to integrin ligands, we will mainly focus on the well-characterized interactions of the two extracellular matrix (ECM) glycoproteins fibronectin (FN) and vitronectin (VN) with cell-surface ligands, and, how this affects activity through the IGF axis. However, we will also highlight the importance of other integrin activation mechanisms and their impact on IGF activity. J. Cell. Physiol. 224: 605–611, 2010. © 2010 Wiley-Liss, Inc.