Ritchie Ho and Constantinos Chronis contributed equally to this work.
Mechanistic insights into reprogramming to induced pluripotency†
Version of Record online: 25 JAN 2011
Copyright © 2010 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 226, Issue 4, pages 868–878, April 2011
How to Cite
Ho, R., Chronis, C. and Plath, K. (2011), Mechanistic insights into reprogramming to induced pluripotency. J. Cell. Physiol., 226: 868–878. doi: 10.1002/jcp.22450
- Issue online: 25 JAN 2011
- Version of Record online: 25 JAN 2011
- Accepted manuscript online: 13 OCT 2010 12:00AM EST
- Manuscript Accepted: 15 SEP 2010
- Manuscript Received: 13 SEP 2010
- Training Grant of the National Institutes of Health. Grant Number: 5T32AI060567-07
- California Institute for Regenerative Medicine (CIRM) Training Award. Grant Number: TG2-01169
- NIH Director's Young Innovator Award. Grant Number: DP2OD001686
- CIRM Young Investigator Award. Grant Number: RN1-00564
Induced pluripotent stem (iPS) cells can be generated from various embryonic and adult cell types upon expression of a set of few transcription factors, most commonly consisting of Oct4, Sox2, cMyc, and Klf4, following a strategy originally published by Takahashi and Yamanaka (Takahashi and Yamanaka, 2006, Cell 126: 663–676). Since iPS cells are molecularly and functionally similar to embryonic stem (ES) cells, they provide a source of patient-specific pluripotent cells for regenerative medicine and disease modeling, and therefore have generated enormous scientific and public interest. The generation of iPS cells also presents a powerful tool for dissecting mechanisms that stabilize the differentiated state and are required for the establishment of pluripotency. In this review, we discuss our current view of the molecular mechanisms underlying transcription factor-mediated reprogramming to induced pluripotency. J. Cell. Physiol. 226: 868–878, 2011. © 2010 Wiley-Liss, Inc.