Special Review Series Article
Numerous isoforms of Fgf8 reflect its multiple roles in the developing brain
Article first published online: 19 APR 2011
Copyright © 2010 Wiley-Liss, Inc.
Journal of Cellular Physiology
Volume 226, Issue 7, pages 1722–1726, July 2011
How to Cite
Sunmonu, N. A., Li, K. and Li, J. Y.H. (2011), Numerous isoforms of Fgf8 reflect its multiple roles in the developing brain. J. Cell. Physiol., 226: 1722–1726. doi: 10.1002/jcp.22587
- Issue published online: 19 APR 2011
- Article first published online: 19 APR 2011
- Accepted manuscript online: 16 DEC 2010 12:00AM EST
- Manuscript Accepted: 30 NOV 2010
- Manuscript Received: 29 NOV 2010
- NIH. Grant Number: R01HD050474
- March of Dimes Foundation
Soluble growth factors play an important role in the coordination and integration of cell proliferation, differentiation, fate determination, and morphogenesis during development of multicellular organisms. Fibroblast growth factors (FGFs) are a large family of polypeptide growth factors that are present in organisms ranging from nematodes to humans. RNA alternative splicing of FGFs and their receptors further enhances the complexity of this ligand-receptor system. The mouse Fgf8 gene produces eight splice variants, which encode isoform proteins with different N-termini and distinct receptor-binding affinity and biological activity. In this article, we review the roles of Fgf8 in vertebrate development and summarize the recent findings on the in vivo function of different Fgf8 splice variants. We propose that multiple Fgf8 isoform proteins act in concert to regulate the overall function of Fgf8 and account for the diverse and essential role of Fgf8 during vertebrate development. J. Cell. Physiol. 226: 1722–1726, 2011. © 2010 Wiley-Liss, Inc.