Regulation of reactive oxygen species in stem cells and cancer stem cells
Article first published online: 23 NOV 2011
Copyright © 2011 Wiley Periodicals, Inc.
Journal of Cellular Physiology
Volume 227, Issue 2, pages 421–430, February 2012
How to Cite
Kobayashi, C. I. and Suda, T. (2012), Regulation of reactive oxygen species in stem cells and cancer stem cells. J. Cell. Physiol., 227: 421–430. doi: 10.1002/jcp.22764
- Issue published online: 23 NOV 2011
- Article first published online: 23 NOV 2011
- Accepted manuscript online: 29 MAR 2011 08:56AM EST
- Manuscript Accepted: 21 MAR 2011
- Manuscript Received: 19 MAR 2011
Stem cells are defined by their ability to self-renew and their multi-potent differentiation capacity. As such, stem cells maintain tissue homeostasis throughout the life of a multicellular organism. Aerobic metabolism, while enabling efficient energy production, also generates reactive oxygen species (ROS), which damage cellular components. Until recently, the focus in stem cell biology has been on the adverse effects of ROS, particularly the damaging effects of ROS accumulation on tissue aging and the development of cancer, and various anti-oxidative and anti-stress mechanisms of stem cells have been characterized. However, it has become increasingly clear that, in some cases, redox status plays an important role in stem cell maintenance, i.e., regulation of the cell cycle. An active area of current research is redox regulation in various cancer stem cells, the malignant counterparts of normal stem cells that are viewed as good targets of cancer therapy. In contrast to cancer cells, in which ROS levels are increased, some cancer stem cells maintain low ROS levels, exhibiting redox patterns that are similar to the corresponding normal stem cell. To fully elucidate the mechanisms involved in stem cell maintenance and to effectively target cancer stem cells, it is essential to understand ROS regulatory mechanisms in these different cell types. Here, the mechanisms of redox regulation in normal stem cells, cancer cells, and cancer stem cells are reviewed. J. Cell. Physiol. 227: 421–430, 2012. © 2011 Wiley Periodicals, Inc.