Cellular modeling of cancer invasion: Integration of in silico and in vitro approaches

Authors

  • Yoonseok Kam,

    Corresponding author
    1. Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida
    • H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612.
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  • Katarzyna A. Rejniak,

    1. Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida
    2. Department of Oncologic Sciences, University of South Florida College of Medicine, Tampa, Florida
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  • Alexander R.A. Anderson

    1. Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida
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Abstract

Cancer invasion is one of the hallmarks of cancer and a prerequisite for cancer metastasis. However, the invasive process is very complex, depending on multiple correlated intrinsic and environmental factors, and thus is difficult to study experimentally in a fully controlled way. Therefore, there is an increased demand for interdisciplinary integrated approaches combining laboratory experiments with multiscale in silico modeling. In this review, we will summarize current computational techniques applicable to model cancer invasion in silico, with a special focus on a class of individual-cell-based models developed in our laboratories. We also discuss their integration with traditional and novel in vitro experimentation, including new invasion assays whose design was inspired by computational modeling. J. Cell. Physiol. 227: 431–438, 2012. © 2011 Wiley Periodicals, Inc.

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