Get access

MicroRNAs in the midst of myeloid signal transduction

Authors

  • Sara L. Stoffers,

    1. Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
    Search for more papers by this author
  • Sara E. Meyer,

    1. Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
    Search for more papers by this author
  • H. Leighton Grimes

    Corresponding author
    1. Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
    2. Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
    • Cincinnati Children's Hospital Medical Center, Division of Immunobiology—MLC 7038, 3333 Burnet Avenue, Room S5.224, Cincinnati, OH 45229-3039.
    Search for more papers by this author

Abstract

MicroRNA (miRNA) play important roles in the development and physiological function of hematopoietic stem/progenitor and mature cell lineages. In addition, deregulated miRNA expression and subsequent gene expression changes are associated with hematologic diseases including myelodysplastic syndromes and acute myeloid leukemia. This review focuses on myelopoiesis as a model to highlight the involvement of miRNA in the regulation of normal and malignant cellular signaling pathways. By incorporating miRNA regulation into well-established myeloid signal transduction pathways, we hope to shed light on targetable factors both upstream and downstream of miRNA signaling. These pathway-specific miRNA functions suggest scenarios wherein miRNA-based therapeutics may be beneficial either alone or in combination with current therapies. J. Cell. Physiol. 227: 525–533, 2012. © 2011 Wiley Periodicals, Inc.

Ancillary