AKT as locus of cancer positive feedback loops and extreme robustness
Article first published online: 23 NOV 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Cellular Physiology
Volume 228, Issue 3, pages 522–524, March 2013
How to Cite
Radisavljevic, Z. (2013), AKT as locus of cancer positive feedback loops and extreme robustness. J. Cell. Physiol., 228: 522–524. doi: 10.1002/jcp.24167
- Issue published online: 23 NOV 2012
- Article first published online: 23 NOV 2012
- Accepted manuscript online: 25 JUL 2012 07:04AM EST
- Manuscript Accepted: 16 JUL 2012
- Manuscript Received: 11 JUL 2012
A positive feedback loops induce extreme robustness in metastatic cancer, relapsed leukemia, myeloma or lymphoma. The loops are generated by the signaling interactome networks of autocrine and paracrine elements from cancer hypoxic microenvironment. The elements of the networks are signaling proteins synthesized in hypoxic microenvironment such as the vascular endothelial growth factor, HIF-1α, hepatocyte growth factor, and molecules nitric oxide and H2O2. The signals from upstream or rebound downstream pathways are amplified by the short or wide positive feedback loops, hyperstimulating AKT-inducing cancer extreme robustness. Targeting the phosphorylated AKT locus by an oxidant/antioxidant modulation induces collapse of positive feedback loops and establishment of negative feedback loops leading to stability of the system and disappearance of cancer extreme robustness. This is a new principle for the conversion of cancer positive loops into negative feedback loops by the locus chemotherapy. J. Cell. Physiol. 228: 522–524, 2013. © 2012 Wiley Periodicals, Inc.