The decline and fall of the IGF-I receptor

Authors

  • Renato Baserga

    Corresponding author
    1. Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania
    • Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107.
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Abstract

This review examines the effect of targeting the insulin-like growth factor 1 receptor (IGF-IR) in human cancers. The results are disappointing. The causes for the failure are discussed, as well as the possible use of the IGF-IR as a secondary target. J. Cell. Physiol. 228: 675–679, 2013. © 2012 Wiley Periodicals, Inc.

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