The author declares no conflict of interest.
Is unconventional secretion inhibited during cell division by Cdk1 activity?†
Version of Record online: 28 JAN 2013
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Cellular Physiology
Volume 228, Issue 5, pages 915–916, May 2013
How to Cite
Tang, B. L. (2013), Is unconventional secretion inhibited during cell division by Cdk1 activity?. J. Cell. Physiol., 228: 915–916. doi: 10.1002/jcp.24264
- Issue online: 28 JAN 2013
- Version of Record online: 28 JAN 2013
- Accepted manuscript online: 19 OCT 2012 07:08AM EST
- Manuscript Accepted: 8 OCT 2012
- Manuscript Received: 13 JUL 2012
- NUS Graduate School of Integrative Sciences and Engineering
A process of unconventional secretion that is dependent on the Golgi stacking protein GRASP and multiple components of the autophagy machinery has recently been documented for several cytoplasmic and membrane protein. Classical secretion via the exocytic pathway is inhibited during cell division in animal cells, as key membrane compartments, particularly the Golgi, are disassembled and fragmented. The question as to whether unconventional secretion is likewise inhibited during mitosis has not been explored. This mode of secretion supposedly bypasses the Golgi. However, GRASP and Vps34 (a key autophagy protein) are both substrates of the cell cycle regulating cyclin-dependent kinase 1 (Cdk1), and their activities are apparently inhibited by Cdk1 phosphorylation. Is unconventional secretion therefore similarly inhibited during cell division like conventional secretion? The story may yet turn out to be more complicated. J. Cell. Physiol. © 2012 Wiley Periodicals, Inc.