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Role of Hippo Signaling in Cancer Stem Cells

Authors

  • Jin Hao,

    1. Department of Orthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, Chengdu, China
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  • Yueling Zhang,

    1. Department of Orthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, Chengdu, China
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  • Dian Jing,

    1. Department of Orthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, Chengdu, China
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  • Yu Li,

    1. Department of Orthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, Chengdu, China
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  • Juan Li,

    Corresponding author
    1. Department of Orthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, Chengdu, China
    • Correspondence to: Juan Li and Zhihe Zhao, Department of Orthodontics, State Key Laboratory of Oral Diseases, West China Stomatology Hospital, Sichuan University, #14, 3rd Section of Renmin South Road, Chengdu 610041, P.R. China.

      E-mail: lijuan@scu.edu.cn (J. Li), zhzhao@scu.edu.cn (Z. H. Zhao)

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  • Zhihe Zhao

    Corresponding author
    1. Department of Orthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, Chengdu, China
    • Correspondence to: Juan Li and Zhihe Zhao, Department of Orthodontics, State Key Laboratory of Oral Diseases, West China Stomatology Hospital, Sichuan University, #14, 3rd Section of Renmin South Road, Chengdu 610041, P.R. China.

      E-mail: lijuan@scu.edu.cn (J. Li), zhzhao@scu.edu.cn (Z. H. Zhao)

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  • Conflict of Interest: The authors declare no conflict of interest.

Abstract

Cancer stem cells (CSCs) have been proposed and evidenced as the initiator of tumor formation and the seeds of metastases. Thereby, the molecular mechanisms regarding modulation of CSCs have been widely explored, aimed to improve treatment for cancer patients. Recent progress has highlighted the effects of Hippo signaling in tumorigenesis and cancer development, including its crucial role in CSC regulation. Although the kernel Hippo signaling cascade has been well studied, its upstream inputs and downstream transcriptional regulation still remain elusive. In this review, we summarize the current understanding of the mechanism and regulatory function of Hippo signaling in CSCs, with emphasis on its possible roles in regulation of CSC self-renewal, differentiation and tumorigenesis. J. Cell. Physiol. 229: 266–270, 2014. © 2013 Wiley Periodicals, Inc.

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