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Induced Neural Lineage Cells as Repair Kits: So Close, Yet So Far Away

Authors

  • Fahimeh Mirakhori,

    1. School of Biology, College of Science, University of Tehran, Tehran, Iran
    2. Department of Stem Cells and Developmental Biology at the Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
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  • Bahman Zeynali,

    1. School of Biology, College of Science, University of Tehran, Tehran, Iran
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  • Ghasem Hosseini Salekdeh,

    1. Department of Molecular Systems Biology at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
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  • Hossein Baharvand

    Corresponding author
    1. Department of Stem Cells and Developmental Biology at the Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
    2. Department of Developmental Biology, University of Science and Culture, ACECR, Tehran, Iran
    • Correspondence to: Hossein Baharvand, Professor of Stem Cells and Developmental Biology, Department of Stem Cells and Developmental Biology at the Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, PO Box 19395-4644, Tehran, Iran.

      E-mail: baharvand@royaninstitute.org

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  • Conflict of interest: None.

Abstract

Transdifferentiation or direct reprogramming of somatic cells into neural lineage cells has provided an invaluable new tool to advance the regenerative neural medicine. Here, we provide an overview of the various strategies currently available for producing of induced neural lineage cells in vitro as well as the direct reprogramming of neural cells in vivo. We also discussing some of the challenges faced in harnessing the potential of induced neural lineage cells for biomedical applications. J. Cell. Physiol. 229: 728–742, 2014. © 2013 Wiley Periodicals, Inc.

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