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jcph131-sm-0001-SuppFig-S1.docx224KFigure S1. Simulated midazolam plasma concentration-time profiles with our generic model 2 following oral dose of 15 and 30 mg midazolam under the rest and the exercise comprising of five sessions (15 minutes at a heart rate of 90 beat/min, 15 minutes at 120 beat/min, 30 minutes at 140 beat/min, 15 minutes at 120 beat/min and 15 minutes at 90 beat/min). The dotted lines represent the therapeutic range of midazolam (50–250 ng/mL).

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