Investigation of an alternative generic model for predicting pharmacokinetic changes during physiological stress
Version of Record online: 12 JUL 2013
© The Author(s) 2013
The Journal of Clinical Pharmacology
Volume 53, Issue 10, pages 1048–1057, October 2013
How to Cite
Peng, H. T., Edginton, A. N. and Cheung, B. (2013), Investigation of an alternative generic model for predicting pharmacokinetic changes during physiological stress. Journal of Clinical Pharma, 53: 1048–1057. doi: 10.1002/jcph.131
- Issue online: 6 SEP 2013
- Version of Record online: 12 JUL 2013
- Manuscript Accepted: 5 JUN 2013
- Manuscript Received: 8 JAN 2013
- Defence Research and Development Canada [14d]
Additional supporting information may be found in the online version of this article at the publisher's web-site.
|jcph131-sm-0001-SuppFig-S1.docx||224K||Figure S1. Simulated midazolam plasma concentration-time profiles with our generic model 2 following oral dose of 15 and 30 mg midazolam under the rest and the exercise comprising of five sessions (15 minutes at a heart rate of 90 beat/min, 15 minutes at 120 beat/min, 30 minutes at 140 beat/min, 15 minutes at 120 beat/min and 15 minutes at 90 beat/min). The dotted lines represent the therapeutic range of midazolam (50–250 ng/mL).|
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