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Figure S1. Relationship between CrCl and canakinumab clearance (estimated by the PK-binding model using the post hoc option of NONMEM) in gouty arthritis patients (line represents the fitting by a power function). CrCl, creatinine clearance; PK, pharmacokinetic.

Table S1. Summary of Canakinumab Clinical Study Designs

Table S2. Summary of Baseline Demographic Parameters

Table S3. Institutional Review Board or Ethics Committee Listings by Center Number

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