Pharmacokinetics of dalfampridine extended release 7.5-mg tablets in healthy subjects and individuals with mild and moderate renal impairment: An open-label study
Version of Record online: 21 OCT 2013
© 2013 The Authors. The Journal of Clinical Pharmacology Published by Wiley Periodicals, Inc. on behalf of The American College of Clinical Pharmacology
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The Journal of Clinical Pharmacology
Volume 54, Issue 1, pages 53–60, January 2014
How to Cite
Samara, E., Winkle, P., Pardo, P., Henney, H. R., Way, S. L., Brown, E., Lee, A. and Blight, A. R. (2014), Pharmacokinetics of dalfampridine extended release 7.5-mg tablets in healthy subjects and individuals with mild and moderate renal impairment: An open-label study. Journal of Clinical Pharma, 54: 53–60. doi: 10.1002/jcph.189
- Issue online: 2 JAN 2014
- Version of Record online: 21 OCT 2013
- Accepted manuscript online: 30 SEP 2013 09:34AM EST
- Manuscript Accepted: 17 SEP 2013
- Manuscript Received: 15 MAY 2013
Additional Supporting Information may be found in the online version of this article at the publisher's web-site.
|jcph189-sm-0001-SupFig-S1.eps||1361K||Figure S1. Scatter plots of the relationship between renal clearance and pharmacokinetic variables related to dalfampridine 7.5-mg exposure under steady-state conditions: Group 1 = subjects with no renal impairment (○); Group 2 = subjects with mild renal impairment (Δ); and Group 3 = subjects with moderate renal impairment (□). Panels A and B demonstrate maximum plasma concentration (Cmax). Panels C and D show the area under the plasma concentration curve over 1 dosing interval of 12 hours (AUC0–12). Panels E and F illustrate the total body clearance (CL/F) corrected for bioavailability. *P < .0001.|
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