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jcph189-sm-0001-SupFig-S1.eps1361KFigure S1. Scatter plots of the relationship between renal clearance and pharmacokinetic variables related to dalfampridine 7.5-mg exposure under steady-state conditions: Group 1 = subjects with no renal impairment (○); Group 2 = subjects with mild renal impairment (Δ); and Group 3 = subjects with moderate renal impairment (□). Panels A and B demonstrate maximum plasma concentration (Cmax). Panels C and D show the area under the plasma concentration curve over 1 dosing interval of 12 hours (AUC0–12). Panels E and F illustrate the total body clearance (CL/F) corrected for bioavailability. *P < .0001.

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