The Journal of Clinical Pharmacology

Cover image for The Journal of Clinical Pharmacology

October 2012

Volume 52, Issue 10

Pages 1456–1614

  1. Pharmacokinetics and Pharmacodynamics

    1. Top of page
    2. Pharmacokinetics and Pharmacodynamics
    3. Pharmacokinetics
    4. Pharmacodynamics
    5. Drug Interaction
    6. Pharmacovigilance
    7. Brief Report
    8. Letter to the Editor
    1. Multiple-Dose Safety, Pharmacokinetics, and Pharmacodynamics of the μ-Opioid Receptor Inverse Agonist GSK1521498 (pages 1456–1467)

      Prof Pradeep J. Nathan, Dr Mark A. Bush, Dr Wenli X. Tao, Dr Annelize Koch, Dr Kirsty M. Davies, Dr Kay Maltby, Dr Barry V. O'Neill, Dr Antonella Napolitano, Dr Andrew L. Skeggs, Dr Allison C. Brooke, Dr Duncan B. Richards, Dr Pauline M. Williams and Prof Edward T. Bullmore

      Article first published online: 7 MAR 2013 | DOI: 10.1177/0091270011421785

    2. Population Pharmacokinetic-Pharmacodynamic Analysis of Istradefylline in Patients With Parkinson Disease (pages 1468–1481)

      Dr William Knebel, Dr Niranjan Rao, Dr T. Uchimura, Dr Akihisa Mori, Ms Jeannine Fisher, Dr Marc R. Gastonguay and Dr Philip Chaikin

      Article first published online: 7 MAR 2013 | DOI: 10.1177/0091270011420566

    3. Pharmacodynamics, Pharmacokinetics, and Safety of AM211: A Novel and Potent Antagonist of the Prostaglandin D2 Receptor Type 2 (pages 1482–1493)

      Dr G. Bain, Dr C. D. King, Mr J. Brittain, Dr J. P. Hartung, Dr I. DeArmond, Dr B. Stearns, Dr Y. P. Truong, Dr J. H. Hutchinson, Dr J. F. Evans and Dr K. Holme

      Article first published online: 7 MAR 2013 | DOI: 10.1177/0091270011421912

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    5. Clopidogrel Pharmacodynamics and Pharmacokinetics in the Fed and Fasted State: A Randomized Crossover Study of Healthy Men (pages 1506–1515)

      Dr Fabrice Hurbin, Dr Xavier Boulenc, Dr Nikki Daskalakis, Dr Christine Farenc, Ms Theresa Taylor, Mr Damien Bonneau, Dr Frank LaCreta, Dr Sue Cheng and Dr Eric Sultan

      Article first published online: 7 MAR 2013 | DOI: 10.1177/0091270011419852

  2. Pharmacokinetics

    1. Top of page
    2. Pharmacokinetics and Pharmacodynamics
    3. Pharmacokinetics
    4. Pharmacodynamics
    5. Drug Interaction
    6. Pharmacovigilance
    7. Brief Report
    8. Letter to the Editor
    1. Plasma and Cerebrospinal Fluid Pharmacokinetics of Naproxen in Children (pages 1516–1526)

      Dr, Mr Pyry Välitalo, Dr, Ms Elina Kumpulainen, Mr Minna Manner, Dr Merja Kokki, Mr Marko Lehtonen, Dr Andrew C. Hooker, Dr Veli-Pekka Ranta and Dr Hannu Kokki

      Article first published online: 7 MAR 2013 | DOI: 10.1177/0091270011418658

    2. Comparison of N-Acetyltransferase-2 Enzyme Genotype-Phenotype and Xanthine Oxidase Enzyme Activity Between Swedes and Koreans (pages 1527–1534)

      Dr Natasa Djordjevic, Dr Juan Antonio Carrillo, Dr Hyung-Keun Roh, Ms Sara Karlsson, Dr Nobuhisa Ueda, Dr Leif Bertilsson and Dr Eleni Aklillu

      Article first published online: 7 MAR 2013 | DOI: 10.1177/0091270011420261

  3. Pharmacodynamics

    1. Top of page
    2. Pharmacokinetics and Pharmacodynamics
    3. Pharmacokinetics
    4. Pharmacodynamics
    5. Drug Interaction
    6. Pharmacovigilance
    7. Brief Report
    8. Letter to the Editor
    1. Romiplostim Dose Response in Patients With Immune Thrombocytopenia (pages 1540–1551)

      Dr J. J. Perez-Ruixo, Dr B. Green, Dr S. Doshi, Dr Y.-M. Wang and Dr D. R. Mould

      Article first published online: 7 MAR 2013 | DOI: 10.1177/0091270011420843

    2. Circadian Intraocular Pressure and Blood Pressure Reduction With Timolol 0.5% Solution and Timogel 0.1% in Patients With Primary Open-Angle Glaucoma (pages 1552–1557)

      Professor, Dr Luciano Quaranta, Dr Andreas Katsanos, Dr Irene Floriani, Dr Ivano Riva, Dr Andrea Russo and Dr Anastasios G. P. Konstas

      Article first published online: 7 MAR 2013 | DOI: 10.1177/0091270011420254

    3. Shortening of the QT Interval After Food Can Be Used to Demonstrate Assay Sensitivity in Thorough QT Studies (pages 1558–1565)

      Dr Jorg Taubel, Dr Alex H. Wong, Dr Asif Naseem, Dr Georg Ferber and Professor A. John Camm

      Article first published online: 7 MAR 2013 | DOI: 10.1177/0091270011419851

  4. Drug Interaction

    1. Top of page
    2. Pharmacokinetics and Pharmacodynamics
    3. Pharmacokinetics
    4. Pharmacodynamics
    5. Drug Interaction
    6. Pharmacovigilance
    7. Brief Report
    8. Letter to the Editor
    1. Effect of Telaprevir on the Pharmacokinetics of Midazolam and Digoxin (pages 1566–1573)

      Dr Varun Garg, Dr Gurudatt Chandorkar, Dr H. Frank Farmer, Dr Frances Smith, Dr Katia Alves and Dr Rolf P. G. van Heeswijk

      Article first published online: 7 MAR 2013 | DOI: 10.1177/0091270011419850

    2. The Pharmacokinetic Interaction Between an Oral Contraceptive Containing Ethinyl Estradiol and Norethindrone and the HCV Protease Inhibitor Telaprevir (pages 1574–1583)

      Dr Varun Garg, Dr Rolf van Heeswijk, Dr Yijun Yang, Dr Robert Kauffman, Dr Frances Smith and Dr Nathalie Adda

      Article first published online: 7 MAR 2013 | DOI: 10.1177/0091270011419855

  5. Pharmacovigilance

    1. Top of page
    2. Pharmacokinetics and Pharmacodynamics
    3. Pharmacokinetics
    4. Pharmacodynamics
    5. Drug Interaction
    6. Pharmacovigilance
    7. Brief Report
    8. Letter to the Editor
    1. Drug Burden Index, Physical Function, and Adverse Outcomes in Older Hospitalized Patients (pages 1584–1591)

      Dr Estelle Lowry, Dr Richard J. Woodman, Dr Roy L. Soiza, Dr Sarah N. Hilmer and Dr Arduino A. Mangoni

      Article first published online: 7 MAR 2013 | DOI: 10.1177/0091270011421489

  6. Brief Report

    1. Top of page
    2. Pharmacokinetics and Pharmacodynamics
    3. Pharmacokinetics
    4. Pharmacodynamics
    5. Drug Interaction
    6. Pharmacovigilance
    7. Brief Report
    8. Letter to the Editor
    1. Increased Bioavailability of 11-Keto-β-Boswellic Acid Following Single Oral Dose Frankincense Extract Administration After a Standardized Meal in Healthy Male Volunteers: Modeling and Simulation Considerations for Evaluating Drug Exposures (pages 1592–1600)

      Dr Carsten Skarke, Dr Karina Kuczka, Dr Lars Tausch, Dr Oliver Werz, Dr Tanja Rossmanith, Dr Jeffrey S. Barrett, Dr Sebastian Harder, Dr Wolfgang Holtmeier and Dr Joachim A. Schwarz

      Article first published online: 7 MAR 2013 | DOI: 10.1177/0091270011422811

    2. Suspected Clonazepam-Induced Bullous Dermatosis in a Patient With Respiratory Failure (pages 1607–1609)

      Mr Ming-Chia Lee, Miss Chiu-Ping Su, Dr Chun-Hua Wang, Dr Chou-Chin Lan and Mr Ta-Wei Wu

      Article first published online: 7 MAR 2013 | DOI: 10.1177/0091270011423923

    3. A Step Toward More Accurate Dosing for Mercaptopurine in Childhood Acute Lymphoblastic Leukemia (pages 1610–1613)

      Dr Hussain Mulla, Dr Andrew Leary, Dr Peter White and Dr Hitesh C. Pandya

      Article first published online: 7 MAR 2013 | DOI: 10.1177/0091270011423663

  7. Letter to the Editor

    1. Top of page
    2. Pharmacokinetics and Pharmacodynamics
    3. Pharmacokinetics
    4. Pharmacodynamics
    5. Drug Interaction
    6. Pharmacovigilance
    7. Brief Report
    8. Letter to the Editor

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