The Journal of Clinical Pharmacology

Cover image for The Journal of Clinical Pharmacology

March 2012

Volume 52, Issue 3

Pages 292–447

  1. Review

    1. Top of page
    2. Review
    3. Pharmacokinetics and Pharmacodynamics
    4. Pharmacokinetics
    5. Pharmacodynamics
    6. Drug Interactions
    7. Brief Report
    8. Letter to the Editor
    1. Efficacy of Metabolic Modulators in Ischemic Heart Disease: An Overview (pages 292–305)

      Bhupinder S. Kalra and Vandana Roy

      Version of Record online: 7 MAR 2013 | DOI: 10.1177/0091270010396042

  2. Pharmacokinetics and Pharmacodynamics

    1. Top of page
    2. Review
    3. Pharmacokinetics and Pharmacodynamics
    4. Pharmacokinetics
    5. Pharmacodynamics
    6. Drug Interactions
    7. Brief Report
    8. Letter to the Editor
    1. Pharmacodynamic Effects on Biochemical Markers of Bone Turnover and Pharmacokinetics of the Cathepsin K Inhibitor, ONO-5334, in an Ascending Multiple-Dose, Phase 1 Study (pages 306–318)

      Mr Shinichi Nagase, Ms Michiyo Ohyama, Mr Yoshitaka Hashimoto, Ms Maria Small, Mr Tomohiro Kuwayama and Dr Steve Deacon

      Version of Record online: 7 MAR 2013 | DOI: 10.1177/0091270011399080

    2. Pharmacokinetics and Pharmacodynamics of AR9281, an Inhibitor of Soluble Epoxide Hydrolase, in Single- and Multiple-Dose Studies in Healthy Human Subjects (pages 319–328)

      Dr Dawn Chen, Dr Randall Whitcomb, Dr Euan MacIntyre, Mr Vinh Tran, Ms Zung N. Do, Dr James Sabry, Dr Dinesh V. Patel, Dr Sampath K. Anandan, Dr Richard Gless and Dr Heather K. Webb

      Version of Record online: 7 MAR 2013 | DOI: 10.1177/0091270010397049

    3. Effect of HMGCR Variant Alleles on Low-Density Lipoprotein Cholesterol—Lowering Response to Atorvastatin in Healthy Korean Subjects (pages 339–346)

      Dr Jae Yong Chung, Dr Sung Kweon Cho, Dr Eun Sil Oh, Dr Dong Hwan Lee, Dr Lay Ahyoung Lim, Mr Seong Bok Jang, Ms Yoon Jung Lee, Dr Kyungsoo Park and Dr Min Soo Park

      Version of Record online: 7 MAR 2013 | DOI: 10.1177/0091270011398239

  3. Pharmacokinetics

    1. Top of page
    2. Review
    3. Pharmacokinetics and Pharmacodynamics
    4. Pharmacokinetics
    5. Pharmacodynamics
    6. Drug Interactions
    7. Brief Report
    8. Letter to the Editor
    1. Application of the Optimal Design Approach to Improve a Pretransplant Drug Dose Finding Design for Ciclosporin (pages 347–360)

      Dr Stefanie Hennig, Mr Joakim Nyberg, Dr Samuel Fanta, Dr Janne T. Backman, Dr Kalle Hoppu, Dr Andrew C. Hooker and Dr Mats O. Karlsson

      Version of Record online: 7 MAR 2013 | DOI: 10.1177/0091270010397731

    2. Time-Dependent Pharmacokinetics of 5-Fluorouracil and Association With Treatment Tolerability in the Adjuvant Setting of Colorectal Cancer (pages 361–369)

      Dr Toni Ibrahim, Dr Antonello Di Paolo, Dr Federica Amatori, Dr Laura Mercatali, Dr Elena Ravaioli, Dr Emanuela Flamini, Dr Emanuele Sacanna, Dr Mario Del Tacca, Dr Romano Danesi and Dr Dino Amadori

      Version of Record online: 7 MAR 2013 | DOI: 10.1177/0091270010396710

    3. From Mouse to Man: Predictions of Human Pharmacokinetics of Orally Administered Docetaxel From Preclinical Studies (pages 370–380)

      Mr S. L. W. Koolen, Dr R. A. B. van Waterschoot, Dr O. van Tellingen, Dr A. H. Schinkel, Dr J. H. Beijnen, Dr J. H. M. Schellens and Dr A. D. R. Huitema

      Version of Record online: 7 MAR 2013 | DOI: 10.1177/0091270010397051

    4. Modeling the Kinetics of Digoxin Absorption: Enhancement by P-Glycoprotein Inhibition (pages 381–387)

      Dr Michael Weiss, Dr Pakawadee Sermsappasuk and Dr Werner Siegmund

      Version of Record online: 7 MAR 2013 | DOI: 10.1177/0091270010396711

    5. Pharmacokinetics, Safety, and Tolerability of Atomoxetine and Effect of CYP2D6*10/*10 Genotype in Healthy Japanese Men (pages 388–403)

      Dr A. Matsui, Dr J. Azuma, Dr J. W. Witcher, Ms A. J. Long, Dr J.-M. Sauer, Dr B. P. Smith, Dr K. A. DeSante, Dr H. A. Read, Dr M. Takahashi and Dr M. Nakano

      Version of Record online: 7 MAR 2013 | DOI: 10.1177/0091270011398657

    6. Population Pharmacokinetic Model for a Novel Oral Hypoglycemic Formed In Vivo: Comparing the Use of Active Metabolite Data Alone Versus Using Data of Upstream and Downstream Metabolites (pages 404–415)

      Dr Helen Kastrissios, Dr Joseph R. Walker, Dr Timothy J. Carrothers, Dr Smita Kshirsagar, Dr Tatiana Khariton, Dr Bahru Habtemariam, Dr Donald E. Mager and Dr Shashank Rohatagi

      Version of Record online: 7 MAR 2013 | DOI: 10.1177/0091270010396373

  4. Pharmacodynamics

    1. Top of page
    2. Review
    3. Pharmacokinetics and Pharmacodynamics
    4. Pharmacokinetics
    5. Pharmacodynamics
    6. Drug Interactions
    7. Brief Report
    8. Letter to the Editor
    1. An Oral Inhibitor of p38 MAP Kinase Reduces Plasma Fibrinogen in Patients With Chronic Obstructive Pulmonary Disease (pages 416–424)

      Dr David A. Lomas, Dr David A. Lipson, Dr Bruce E. Miller, Ms Lisa Willits, Mr Oliver Keene, Mrs Helen Barnacle, Dr Neil C. Barnes and Dr Ruth Tal-Singer

      Version of Record online: 7 MAR 2013 | DOI: 10.1177/0091270010397050

    2. Oral Sildenafil Therapy for Chinese Patients With Pulmonary Arterial Hypertension: A Multicenter Study (pages 425–431)

      Dr Chang-Ming Xiong, Dr Xian-Ling Lu, Dr Guang-Liang Shan, Dr Bing-Xiang Wu, Dr Xian-Yang Zhu, Dr Guang-Hua Wu, Dr Xiao-Feng Zeng, Dr Tao Guo, Dr Zhi-Hong Liu, Dr Xin-Hai Ni, Dr Xian-Sheng Cheng, Dr Qing Gu, Dr Zhi-Hui Zhao, Dr Hong-Yan Tian, Dr Wei-Min Li, Dr Duan-Zhen Zhang, Dr Cheng Zhang, Dr Meng-Tao Li, Dr Hong-Min Liu, Dr Ya-Juan Guo, Dr Jie-Yan Shen, Dr Wei-Jun Zhang, Dr Shuang Liu, Dr Da-Xin Zhou, Dr Chun-De Bao, Dr Shi-An Huang, Dr Jian-Ying Chen, Dr Wei-Feng Wu, Dr Kai Huang, Dr Chang-ling Li, Dr Li-Hua Wang, Dr Bei He, Dr Jian-Guo He and Dr Jian-Jun Li

      Version of Record online: 7 MAR 2013 | DOI: 10.1177/0091270011398241

  5. Drug Interactions

    1. Top of page
    2. Review
    3. Pharmacokinetics and Pharmacodynamics
    4. Pharmacokinetics
    5. Pharmacodynamics
    6. Drug Interactions
    7. Brief Report
    8. Letter to the Editor
    1. Influence of Different Proton Pump Inhibitors on Activity of Cytochrome P450 Assessed by [13C]-Aminopyrine Breath Test (pages 432–439)

      Dr Chise Kodaira, Dr Shinya Uchida, Dr Mihoko Yamade, Dr Masafumi Nishino, Dr Mutsuhiro Ikuma, Dr Noriyuki Namiki, Dr Mitsushige Sugimoto, Dr Hiroshi Watanabe, Dr Akira Hishida and Dr Takahisa Furuta

      Version of Record online: 7 MAR 2013 | DOI: 10.1177/0091270010397728

  6. Brief Report

    1. Top of page
    2. Review
    3. Pharmacokinetics and Pharmacodynamics
    4. Pharmacokinetics
    5. Pharmacodynamics
    6. Drug Interactions
    7. Brief Report
    8. Letter to the Editor
    1. Limited Sampling Strategies for the Estimation of Raltegravir Daily Exposure in HIV-Infected Patients (pages 440–445)

      Dr Dario Cattaneo, Dr Diego Ripamonti, Dr Cristina Gervasoni, Dr Simona Landonio, Dr Paola Meraviglia, Dr Sara Baldelli, Dr Valeria Cozzi, Dr Serena Fucile and Dr Emilio Clementi

      Version of Record online: 7 MAR 2013 | DOI: 10.1177/0091270010395939

  7. Letter to the Editor

    1. Top of page
    2. Review
    3. Pharmacokinetics and Pharmacodynamics
    4. Pharmacokinetics
    5. Pharmacodynamics
    6. Drug Interactions
    7. Brief Report
    8. Letter to the Editor
    1. Sodium Alginate in Preterm Infants: Game, Set, and Match? (page 446)

      John N. van den Anker

      Version of Record online: 7 MAR 2013 | DOI: 10.1177/0091270011398242

    2. Authors' Response (page 447)

      Omer Erdeve, Begum Atasay, Saadet Arsan and Tomris Türmen

      Version of Record online: 7 MAR 2013 | DOI: 10.1177/0091270011401738

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