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Figure S1. Arithmetic mean baseline and post-dose systolic and diastolic blood pressure by AP301 dose group (N = 6) and pooled placebo recipients (N = 12).

Figure S2. Arithmetic mean baseline and post-dose PQ and QTc intervals of the ECG by AP301 dose group (N = 6) and pooled placebo recipients (N = 12).

Table S1. FVC (L) Assessed Before and After Inhalation of AP301 or Matching Placebo for Each Dose Level and Overall

Table S2. FEV1 (L) Assessed Before and After Inhalation of AP301 or Matching Placebo for Each Dose Level and Overall

Table S3. Summary of Arithmetic Mean (±SD) Baseline and Post-Dose Exhaled Nitric Oxide (eNO) Values by AP301 Dose Group (N = 6) and Pooled Placebo Recipients (N = 12)

Table S4. Summary of Arithmetic Mean (±SD) Baseline and Post-Dose Heart Rate (HR) Values by AP301 Dose Group (N = 6) and Pooled Placebo Recipients (N = 12)

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