Additional supporting information may be found in the online version of this article at the publisher's web-site.

jcph205-sm-0001-SupFig-S1.doc206KFigure S1. Individual weight adjusted apparent clearance normalized to body weight versus age. Individual weight adjusted apparent clearance calculated as the individual post-hoc estimate of clearance from the final model divided by the individual body weight to the 3/4 power.
jcph205-sm-0002-SupFig-S2.doc38KFigure S2. Plasma alpha-1 acid glycoprotein (AAG) concentrations versus age. Grey line-lowess fit curve.
jcph205-sm-0003-SupTab-S1.doc45KTable S1. Summary of Clinical Studies Providing Data for the Population Pharmacokinetic Analysis

Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.