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Figure S1. Relationship between dabrafenib, hydroxy-dabrafenib, carboxy-dabrafenib, and desmethyl-dabrafenib trough concentrations.

Figure S2. Goodness of fit for final PK model.

Figure S3. Prediction-corrected visual predictive check for final PK model.

Figure S4. Effects of covariates on trough concentrations for dabrafenib, hydroxy-, carboxy, and desmethyl-dabrafenib from the full models.

Table S1. Summary of the Clinical Studies Included in the Population Pharmacokinetic Analysis

Table S2. Covariates Evaluated in the Full Model for Each Pharmacokinetic Parameter

Table S3. Subject Demographics

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