Modeling of 24-hour glucose and insulin profiles in patients with type 2 diabetes mellitus treated with biphasic insulin aspart
Version of Record online: 11 MAR 2014
© 2014, The American College of Clinical Pharmacology
The Journal of Clinical Pharmacology
Volume 54, Issue 7, pages 809–817, July 2014
How to Cite
Røge, R. M., Klim, S., Kristensen, N. R., Ingwersen, S. H. and Kjellsson, M. C. (2014), Modeling of 24-hour glucose and insulin profiles in patients with type 2 diabetes mellitus treated with biphasic insulin aspart. Journal of Clinical Pharma, 54: 809–817. doi: 10.1002/jcph.270
- Issue online: 5 JUN 2014
- Version of Record online: 11 MAR 2014
- Accepted manuscript online: 21 JAN 2014 12:35AM EST
- Manuscript Accepted: 16 JAN 2014
- Manuscript Received: 10 DEC 2013
Additional supporting information may be found in the online version of this article at the publisher's web-site.
Figure S1. Time courses for plasma glucose, endogenous insulin and exogenous insulin concentrations for a representative individual from trial 2. The dots show the data and the lines show the model fit.
Figure S2. Goodness of fit plots for the final model. Observations versus population predictions and individual predictions.
Figure S3. Conditional weighted residuals and weighted residuals versus time.
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