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Figure S1. The chemical structure of ONO-5334. ONO-5334 (N-((1S)-3-{(2Z)-2-[(4R)-3,4-dimethyl-1,3-thiazolidin-2-ylidene]hydrazino}-2,3-dioxo-1-(tetrahydro-2H-pyran-4-yl)propyl) cycloheptanecarboxamide) (Ono Pharmaceutical Co., Ltd., Osaka, Japan).

Figure S2. Goodness of fit plots for (a) plasma concentration of ONO-5334, (b) %CFB LS BMD, and (c) %CFB Hip BMD. CWRES, conditional weighted residuals. The symbols of square represent observed data. Solid curve and line represent LOESS (locally weighted scatterplot smoothing) fit and unity, respectively. %CFB, percent change from baseline; LS, lumbar spine; Hip, total hip; BMD, bone mineral density.

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