SEARCH

SEARCH BY CITATION

Additional supporting information may be found in the online version of this article at the publisher's web-site.

FilenameFormatSizeDescription
jcph302-sm-0001-SuppData.doc223K

Supporting Information Figure S1. Scatter plots and slope lines for QT correction methods QTcF, QTcB, and QTcI versus RR. Data for each treatment group are given, though these represent pre-dose values. QTcF was the most appropriate method of QT correction in this study.

Supporting Information Table S1. Primary Outcome: Least Squares (LS) Mean of Treatment Differences From Placebo for QTcF Change From Baseline (∆∆QTcF) and 90% Confidence Intervals.

Supporting Information Table S2. Secondary Outcome: Least squares (LS) Mean of Treatment Differences From Placebo for Heart Rate (HR) Change From Baseline (∆∆HR) and 90% Confidence Intervals.

Supporting Information Table S3. Safety ECG Analysis: Maximum Post-Dose QTcF Interval and Maximum Change in QTcF Versus Baseline.

Supporting Information Table S4. Summary of All Adverse Events Occurring in Two or More Subjects in Any Treatment Group by System Organ Class (Safety Population).

Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.